PMID: 8591738Oct 1, 1995Paper

Segregation of pigment cell anomalies in Munich miniature swine (MMS) Troll crossed with German Landrace

DTW. Deutsche tierärztliche Wochenschrift
S MüllerO Distl

Abstract

In order to study the inheritance of melanocytic lesions in the Munich Miniature Swine (MMS) Troll, we established the F1-, F2- and R1-generations, starting with one melanoma-bearing MMS-Troll boar and four German Landrace sows as founder animals. A total of 168 animals were born, 24 in the F1-, 111 in the F2-, 19 in the B1DL-, and 14 in the B1Troll-generation. Benign lesions with lentigoid melanocytic hyperplasia or nests of hyperplastic melanocytes like in human junctional nevus were seen in 10 (41.7%) F1-, 17 (15.3%) F2-, 2 (10.5%) B1DL-, and 6 B1Troll-animals. Malignant melanomas occurred only in the F2-(4 animals; 3.6%) and in the B1Troll-(1 animal; 7.1%) generation. The observed segreation suggests different modes of inheritance for nevi and melanomas. The segregation of nevi can be explained by a major gene model with additional modification by a polygenic component. For melanoma, a major gene model does not fit the data sufficiently. Therefore, a two-or-three-locus model with doubled or tripled recessive affected animals has to be supposed for the inheritance of melanoma. Influence of SLA-haplotypes could not be observed.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.