Segregation of the human basal forebrain using resting state functional MRI

NeuroImage
Ross D MarkelloEve De Rosa

Abstract

The basal forebrain (BF) is poised to play an important neuromodulatory role in brain regions important to cognition due to its broad projections and complex neurochemistry. While significant in vivo work has been done to elaborate BF function in nonhuman rodents and primates, comparatively limited work has examined the in vivo function of the human BF. In the current study we used multi-echo resting state functional magnetic resonance imaging (rs-fMRI) from 100 young adults (18-34 years) to assess the potential segregation of human BF nuclei as well as their associated projections. Multi-echo processing provided significant gains in SNR throughout the brain as compared to traditional single-echo processing, with some of the largest increases observed in the BF. Bottom-up clustering of voxel-wise BF functional connectivity maps yielded adjacent functional clusters within the BF that closely aligned with the distinct, hypothesized nuclei important to cognition: the nucleus basalis of Meynert (NBM) and the medial septum/diagonal band of Broca (MS/DB). Examining their separate functional connections, the NBM and MS/DB revealed distinct projection patterns, suggesting a conservation of nuclei-specific functional connectivity with h...Continue Reading

Citations

Jan 5, 2018·Psychological Research·Kesong Hu
Sep 8, 2019·Nature Reviews. Neuroscience·Randy L Buckner, Lauren M DiNicola
Dec 19, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Archana Iyer, Shubha Tole
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Jan 12, 2020·Communications Biology·Pedro Nascimento AlvesMichel Thiebaut de Schotten
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Jan 3, 2022·Cerebral Cortex·Ben J HarrisonTrevor Steward

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