Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala

The European Journal of Neuroscience
A I GulyasT F Freund

Abstract

Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) catalyse the hydrolysis of the endocannabinoids anandamide and 2-arachidonoyl glycerol. We investigated their ultrastructural distribution in brain areas where the localization and effects of cannabinoid receptor activation are known. In the hippocampus, FAAH was present in somata and dendrites of principal cells, but not in interneurons. It was located mostly on the membrane surface of intracellular organelles known to store Ca(2+) (e.g. mitochondria, smooth endoplasmic reticulum), less frequently on the somatic or dendritic plasma membrane. MGL immunoreactivity was found in axon terminals of granule cells, CA3 pyramidal cells and some interneurons. In the cerebellum, Purkinje cells and their dendrites are intensively immunoreactive for FAAH, together with a sparse axon plexus at the border of the Purkinje cell/granule cell layers. Immunostaining for MGL was complementary, the axons in the molecular layer were intensively labelled leaving the Purkinje cell dendrites blank. FAAH distribution in the amygdala was similar to that of the CB(1) cannabinoid receptor: evident signal in neuronal somata and proximal dendrites in the basolateral nucleus, and hardly any labe...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HerkenhamK C Rice
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Sep 21, 2000·The European Journal of Neuroscience·N HájosT F Freund
Dec 1, 2000·Progress in Brain Research·A CalignanoD Piomelli
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·B F CravattA H Lichtman
Aug 22, 2001·European Journal of Pharmacology·N Stella, D Piomelli
Nov 9, 2001·Nature·F Rodríguez de FonsecaD Piomelli
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Aron H LichtmanBenjamin F Cravatt
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·T P DinhD Piomelli

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Citations

Sep 29, 2007·Journal of Molecular Neuroscience : MN·David M Lovinger
Jan 25, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vinogran NaidooBen A Bahr
Aug 21, 2013·Neuropharmacology·Daniele Piomelli
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Christopher J FowlerStig O P Jacobsson
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Tiziana BisognoVincenzo Di Marzo
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·María Ruth PazosJulián Romero
Apr 10, 2013·Trends in Endocrinology and Metabolism : TEM·Daniele Piomelli
Dec 12, 2013·Trends in Pharmacological Sciences·Ozge Gunduz-CinarAndrew Holmes
Apr 24, 2008·Chemical Reviews·Kay AhnBenjamin F Cravatt
Sep 9, 2008·Nature Medicine·István Katona, Tamás F Freund
Nov 22, 2011·Nature Neuroscience·Jin FuDaniele Piomelli
Mar 6, 2012·Nature Neuroscience·Giovanni BénardGiovanni Marsicano
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillBoris B Gorzalka
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Divya RameshAron H Lichtman
Mar 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K Mackie
Jul 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Asami TanimuraMasanobu Kano
Nov 21, 2009·The Journal of Biological Chemistry·Martin KaczochaDale G Deutsch
Jul 5, 2006·The Cerebellum·Patrick K SafoWade G Regehr
Mar 14, 2007·Current Opinion in Lipidology·Vincenzo Di Marzo, Stefania Petrosino
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melina ReisenbergPatrick Doherty
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Maurice R Elphick
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jul 7, 2009·Annual Review of Physiology·Boris D Heifets, Pablo E Castillo
Jun 27, 2006·The AAPS Journal·Ken Mackie, Nephi Stella
Jan 20, 2007·The AAPS Journal·Andrea G Hohmann, Richard L Suplita
Feb 27, 2010·The AAPS Journal·Nadine M Ulloa, Dale G Deutsch
Jan 21, 2011·PloS One·Carsten ZschenderleinDoris Albrecht
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Silvia MarinelliAlberto Bacci
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik KeimpemaTibor Harkany
Nov 5, 2013·European Journal of Pharmacology·Keith A SharkeyLinda A Parker
May 27, 2014·European Journal of Pharmacology·Jenny L WileyRobert E Vann
May 7, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tiziano BandieraDaniele Piomelli
Apr 22, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Iffat Ara Sonia RahmanNatsuo Ueda
Apr 25, 2012·Annual Review of Neuroscience·István Katona, Tamás F Freund
Feb 11, 2014·Molecular Neurobiology·Elizabeth Sabens LiedhegnerCecilia J Hillard

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