Segregation ratios within Segregation Distorter lines of Drosophila melanogaster conform to a beta-binomial distribution

Genetical Research
C B Sharp, A J Hilliker

Abstract

Segregation Distorter (SD) chromosomes are preferentially recovered from SD/SD+ males due to the dysfunction of sperm bearing the SD+ chromosome. The proportion of offspring bearing the SD chromosome is given the symbol k. The nature of the frequency distribution of k was examined by comparing observed k distributions produced by six different SD chromosomes, each with a different mean, with k distributions predicted by two different statistical models. The first model was one where the k of all males with a given SD chromosome were considered to be equal prior to the determination of those gametes which produce viable zygotes. In this model the only source of variation of k would be binomial sampling. The results rigorously demonstrated for the first time that the observed k distributions did not fit the prediction that the only source of variation was binomial sampling. The next model tested was that the prior distribution of segregation ratios conformed to a beta distribution, such that the distribution of k would be a beta-binomial distribution. The predicted distributions of this model did not differ significantly from the observed distributions of k in five of the six cases examined. The sixth case probably failed to fit ...Continue Reading

References

Nov 1, 1958·Annals of Human Genetics·A W EDWARDS
Oct 1, 1979·Genetics·D W Martin, Y Hiraizumi
Jul 1, 1980·Genetics·Y HiraizumiI A Eckstrand

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