Seizure and Psychosocial Outcomes of Childhood and Juvenile Onset Generalized Epilepsies: Wolf in Sheep's Clothing, or Well-Dressed Wolf?

Epilepsy Currents
Katherine Nickels

Abstract

Studies of generalized electroclinical syndromes can provide guidance regarding long-term seizure, cognitive, and psychosocial outcomes. Childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy, and idiopathic generalized epilepsy with generalized tonic-clonic seizures alone are electroclinical syndromes typically associated with normal intellect and good response to antiseizure medications. However, studies have demonstrated significantly poorer psychosocial outcomes than expected for these syndromes, regardless of seizure control. Potential causes for this include underlying abnormalities in social skills, social stigma, and underlying abnormalities in brain development and maturation.

References

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Citations

Jan 20, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Martin HoltkampBernd J Vorderwülbecke
May 4, 2017·Epilepsia·Bernd J VorderwülbeckeMartin Holtkamp
Dec 13, 2018·Frontiers in Synaptic Neuroscience·Pavlos RigasIrini Skaliora

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