Seizure-Induced Increased 18F-DOPA Uptake in a Child With Diffuse Astrocytoma and Transient Brain MRI Abnormalities Related to Status Epilepticus

Clinical Nuclear Medicine
Giovanni MoranaArnoldo Piccardo

Abstract

We report the finding of increased F-DOPA uptake in the brain parenchyma surrounding a temporoparietal low-grade diffuse astrocytoma and corresponding to transient seizure-induced MRI abnormalities. There was concomitant markedly increased tumoral uptake. This F-DOPA PET phenomenon may represent increased amino acid transport induced by seizures. In the setting of brain tumor imaging, increased F-DOPA uptake of low-grade epileptogenic tumors and adjacent brain parenchyma should be carefully interpreted in light of clinical and electroencephalographic findings related to seizure activity.

References

Jun 22, 2013·European Journal of Radiology·A CianfoniC Colosimo
Aug 16, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Constantin LapaKen Herrmann
Feb 26, 2016·Clinical Nuclear Medicine·Giovanni MoranaAndrea Rossi
May 9, 2016·Seizure : the Journal of the British Epilepsy Association·Amélia Mendes, Luísa Sampaio
Jul 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Markus HuttererEugen Trinka

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Citations

Oct 22, 2020·Journal of Neurology·Dimitri RenardJean Sebastien Guillamo

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