Seizure-like activity in the hypoglycemic rat: lack of correlation with the electroencephalogram of free-moving animals

Epilepsy Research
Martin Del CampoLiang Zhang

Abstract

The neuropathology of hypoglycemia and its mechanisms have been well studied. However, the physiopathogenesis of hypoglycemia-related seizures has escaped elucidation. Various animal models reportedly show "seizures" when rendered hypoglycemic, however, correlation with the electroencephalogram (EEG) is inconsistent. In order to characterize the role of the hippocampus and frontal neocortex in the generation of hypoglycemic seizures, this study was undertaken. Adult rats were implanted stereotaxically with electrodes in the left hippocampus and right frontal cortex. After 1 week, they were fasted 18-24h, then injected intraperitoneally with insulin, 35 IU/kg. Simultaneous EEG/video monitoring was conducted. Interpretable EEG recordings were obtained in 8/12 animals. Two showed poor association of seizure-like behaviour (neck extension, vocalizations, tonic extension of the tail, digging or running limb movements) with ictal EEG patterns. Four animals exhibited such behaviours during periods of high amplitude polymorphic slow wave activity, burst-suppression patterns or non-rhythmic spiking. Two others were encephalopathic (behaviourally and electroencephalographically) until death. Not all animals develop seizure-like behaviour...Continue Reading

References

May 27, 2003·Diabetes Care·Philip E CryerHarry Shamoon
Nov 1, 1954·Electroencephalography and Clinical Neurophysiology·F A GIBBS, E L MURRAY
Mar 1, 1957·A.M.A. Archives of Neurology and Psychiatry·T TOKIZANE
Dec 13, 2003·Science·A J McMichaelCarl Folke
Dec 19, 2003·Pediatric Research·Kelvin A YamadaDaniel G Herrera
Mar 24, 2006·The European Journal of Neuroscience·Anne KirchnerLibor Velísek
Oct 4, 2007·Epilepsia·Jana VelískováLibor Velísek

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