Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.

Acta Neuropathologica
Till S ZimmerEleonora Aronica


Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epileptogenic brain have not been addressed in detail. Iron-related neuropathology and antioxidant metabolic processes were investigated in resected brain tissue from patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS), post-mortem brain tissue from patients who died after status epilepticus (SE) as well as brain tissue from the electrically induced SE rat model of TLE. Magnetic susceptibility of the presumed seizure-onset zone from three patients with focal epilepsy was compared during and after seizure activity. Finally, the cellular effects of iron overload were studied in vitro using an acute mouse hippocampal slice preparation and cultured human fetal astrocytes. While iron-accumulating neurons had a pyknotic morphology, astrocytes appeared to acquire iron-sequestrating capacity as indicated by prominent ferritin expression and iron retention in the hippocampus of patients with SE or TLE. Interictal to postictal comparison revealed increased magnetic susceptibilit...Continue Reading


Nov 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·T KawanamiT Katagiri
May 24, 1997·Biochimica Et Biophysica Acta·W Chua-anusornT G St Pierre
Mar 5, 2003·Journal of the Neurological Sciences·Ruben VidalBernardino Ghetti
Jan 22, 2005·The EMBO Journal·Alexander YaruninEduard C Hurt
Mar 16, 2005·The Journal of Biological Chemistry·Kazuhiro HondaGeorge Perry
Oct 14, 2005·Journal of Cellular Physiology·Wei SongHyman M Schipper
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suh Young Jeong, Samuel David
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan A GorterWytse J Wadman
Nov 25, 2006·Brain : a Journal of Neurology·E A van VlietJ A Gorter
Apr 4, 2007·Neurochemical Research·Julie A GaaschCornelis J Van der Schyf
Jun 15, 2007·Archives of Histology and Cytology·Reiko MeguroKazuhiko Shoumura
Dec 21, 2007·Neuroscience·E AronicaJ A Gorter
Nov 6, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva K WirthUlrich Schweizer
Jan 22, 2010·Pflügers Archiv : European journal of physiology·Gerald W ZamponiEdward Perez-Reyes
Jun 29, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Matthew SchragWolff Kirsch
Jul 7, 2010·Cell·Matthias W HentzeClara Camaschella
Feb 23, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helena ParfenovaAlexander L Fedinec
May 29, 2012·Cell·Scott J DixonBrent R Stockwell
Sep 8, 2012·Genome Research·Jennifer HarrowTim J Hubbard
Feb 16, 2013·Free Radical Biology & Medicine·Shane Rowley, Manisha Patel
May 21, 2013·Annals of Neurology·Manuela MazzuferiRafal M Kaminski
Oct 29, 2013·Journal of Neuroinflammation·Romina MaccoDaniele Zacchetti

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