Seizure outcome after anterior temporal lobectomy and its predictors in patients with apparent temporal lobe epilepsy and normal MRI

Epilepsia
P N SylajaP Sankara Sarma

Abstract

Very little reliable information is available regarding the role of anterior temporal lobectomy (ATL), optimal presurgical evaluation strategy, post-ATL seizure outcome, and the factors that predict the outcome in patients with medically refractory temporal lobe epilepsy (TLE) and normal high-resolution magnetic resonance imaging (MRI). To be cost-effective, epilepsy surgery centers in developing countries will have to select candidates for epilepsy surgery by using the locally available technology and expertise. We reviewed the electroclinical and pathological characteristics and seizure outcome of 17 patients who underwent ATL for medically refractory TLE after being selected for ATL based on a noninvasive selection protocol without the aid of positron emission tomography (PET) or single-photon emission computed tomography (SPECT), despite a normal preoperative high-resolution MRI. Seven (41%) patients achieved an excellent seizure outcome; five of them were totally seizure free. An additional five (29%) patients had >75% reduction in seizure frequency. The following pre-ATL factors predicted an excellent outcome: antecedent history of febrile seizures, strictly unilateral anterior temporal interictal epileptiform discharges ...Continue Reading

References

Sep 1, 1993·Journal of Neuropathology and Experimental Neurology·D D Armstrong
Dec 1, 1996·Epilepsy Research·J Engel
Feb 1, 1997·Brain : a Journal of Neurology·J S Duncan
Jul 22, 1998·Epilepsia·S C Schachter, C B Saper
Jan 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C A ScottW F Harkness
Sep 14, 2000·Seizure : the Journal of the British Epilepsy Association·M D HolmesL M Ojemann
Aug 4, 2001·The New England Journal of Medicine·S WiebeUNKNOWN Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group
Jul 24, 2002·Brain : a Journal of Neurology·L TassiR Spreafico
Feb 1, 2003·Epilepsia·Padmavathy N Sylaja, Kurupath Radhakrishnan
Nov 26, 2003·Epilepsia·Teeradej SrikijvilaikulWilliam E Bingaman

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Citations

Jun 5, 2013·JAMA Neurology·Katherine NoeGregory A Worrell
May 4, 2010·Current Neurology and Neuroscience Reports·Kanjana UnnwongseNancy Foldvary-Schaefer
Oct 31, 2013·Clinical Neurology and Neurosurgery·Wyatt L RameyMartin E Weinand
Oct 15, 2013·Epilepsy Research·Chaturbhuj RathoreKurupath Radhakrishnan
May 21, 2009·Nature Reviews. Neurology·Kurupath Radhakrishnan
Jun 17, 2008·Brain : a Journal of Neurology·Fabrice BartolomeiFabrice Wendling
Feb 20, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Giridhar P KalamangalamWilliam M Bingaman
Jul 17, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Cayetano E Napolitano, Miguel A Orriols
Nov 23, 2006·Epilepsia·Thomas BengnerStefan Stodieck
Oct 6, 2007·Epilepsia·Girish K Hiremath, Imad M Najm
Oct 19, 2007·Epilepsia·Ali A Asadi-Pooya, Michael R Sperling
Apr 25, 2009·Epilepsia·Michael L BellGregory A Worrell
Sep 8, 2005·Epilepsy Currents·Theodore H Schwartz
Jun 7, 2013·Continuum : Lifelong Learning in Neurology·John W Miller, Shahin Hakimian
Nov 26, 2008·Journal of Neurosurgery·Alaa Eldin ElsharkawyAlois Ebner
Sep 4, 2010·Annals of Indian Academy of Neurology·P Sarat Chandra, Manjari Tripathi
Feb 20, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Dang Khoa NguyenMaryse Lassonde
Nov 9, 2005·Expert Review of Neurotherapeutics·Amit Ray, Elaine Wyllie
Mar 15, 2015·Epilepsy & Behavior : E&B·Chaturbhuj RathoreKurupath Radhakrishnan
Dec 14, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Fernando L ValeSelim R Benbadis
Apr 4, 2008·Seminars in Ultrasound, CT, and MR·Hans Clusmann
Mar 6, 2007·Epilepsy Research·Ashalatha RadhakrishnanP Sankara Sarma
Dec 17, 2005·Epilepsy & Behavior : E&B·T BengnerS Stodieck

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