Seizure Outcomes After Radiosurgery for Cerebral Arteriovenous Malformations: An Updated Systematic Review and Meta-Analysis

World Neurosurgery
Natasha IronsideJason P Sheehan

Abstract

The seizure outcomes for patients with brain arteriovenous malformations (AVM) who undergo intervention with stereotactic radiosurgery (SRS) are incompletely understood. We sought to determine, in a systematic review and meta-analysis, the rates of seizure control after SRS for patients with AVM-associated seizures and identify predictive factors. We performed a systematic review of PubMed and MEDLINE databases from January 1987 to January 2018, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies reporting post-SRS outcomes data for ≥5 patients with AVM-associated seizures were included. The seizure outcomes and factors associated with seizure freedom were evaluated using meta-analysis. A total of 27 studies, comprising 4826 patients, met the inclusion criteria for analysis. One or more seizures occurred in 1456 of 4826 patients (34.7% [26.0-43.9%]), and the mean follow-up was 48 ± 7 months. Seizure control (seizure freedom or seizure improvement) was achieved in 910 of 1312 patients (73.1% [66.9-78.9%]). Seizure freedom was achieved in 597 of 1245 patients (55.7% [44.5-66.6%]). Of 259 patients with seizure freedom, cessation of antiepileptic drugs was achieved in 175 patien...Continue Reading

Citations

Jul 20, 2019·Journal of Neurointerventional Surgery·John Charles BensonWaleed Brinjikji
Feb 23, 2019·Acta neurochirurgica·Constantin TuleascaMarc Levivier
Nov 23, 2021·Clinical Neuroradiology·Romain CapocciFrédéric Clarençon
Nov 15, 2021·World Neurosurgery·James MooneyWinfield S Fisher
Mar 5, 2019·World Neurosurgery·Ching-Jen ChenUNKNOWN International Radiosurgery Research Foundation

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.