Seizure prevention using carbamazepine following severe brain injuries

Neurochirurgia
F L GlötznerK W Pflughaupt

Abstract

In this article the efficacy of carbamazepine for seizure prophylaxis in severe head injuries is tested. In addition, conditions with high risk of seizures requiring prophylactic regimen, were defined. One hundred and thirty-nine patients above 15 years of age with severe head injuries were included in the study. They were randomly divided into two groups--carbamazepine versus placebo. Prophylaxis was started immediately after the accident and was continued for one and a half to two years. Carbamazepine dosage was adjusted individually to provide serum levels within therapeutic range. In case of a seizure all the necessary clinical management was initiated. Patients on carbamazepine showed a lower probability of post-traumatic seizures than those on placebo (p less than 0.05). This difference was statistically significant with regard to early seizures within the first week and with regard to the follow-up time in total, but not regarding late seizures per se. Brain lesions with a high risk of post-traumatic seizures were situated in the parietal and temporal areas and included acute subdural haematomas in all locations, temporal lobe contusions, parietal epidural haematomas accompanied by other lesions and the deep stages of co...Continue Reading

Citations

Jun 11, 2009·Journal of Neurotrauma·Jeffrey EnglanderThao T Duong
Jan 22, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G Schierhout, I Roberts
Oct 3, 2008·Neurosurgical Focus·Kristen E JonesDavid O Okonkwo
Jan 2, 2014·International Journal of Molecular Sciences·Hanna Algattas, Jason H Huang
Dec 1, 1992·Italian Journal of Neurological Sciences·L MurriG Parenti
Mar 5, 2016·Neurologia Medico-chirurgica·Ryosuke Hanaya, Kazunori Arita
Jul 18, 2020·British Journal of Neurosurgery·Catherine PringleIan Kamaly-Asl

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