PMID: 44544Dec 1, 1979

Seizure proneness and neurotransmitter uptake

Neurochemical Research
S C BondyD B Bettis


The ability of midbrain homogenates from two strains of mice to accumulate several putative neurotransmitters, or their precursor in the case of acetylcholine, has been examined. The high-affinity transport mechanisms toward glutamate, GABA, dopamine, and glycine were similar in both strains. The seizure-prone DBA21BG strain had a significantly higher capacity to transport choline than did the relatively seizure-resistant C57BL/6 IBC mice. Howaver, no difference in the density of muscarinic binding sites in the two mouse strains was found.


Feb 1, 1996·Synapse·M S Starr
Sep 28, 1995·Biochemical Pharmacology·B A FarajR T Jackson
Jan 1, 1984·Annals of Neurology·A V Delgado-Escueta


Jan 7, 1977·Brain Research·S C Bondy, J L Purdy
May 1, 1976·Physiology & Behavior·S C Maxson, J S Cowen
Jan 1, 1976·Developmental Psychobiology·B S DeckardJ C DeFries
Feb 1, 1973·Journal of Neurochemistry·M J KuharG K Aghajanian
Jun 1, 1966·Experimental Neurology·R P Kesner
May 1, 1967·The Journal of Heredity·J L Fuller, F H Sjursen

Related Concepts

Renal Carnitine Transport Defect
Mice, Inbred DBA
Non-epileptic Convulsion
Midbrain Structure
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Choline Hydroxide
Muscarinic Acetylcholine Receptor
Mice, Inbred C57BL

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