Seizure-related regulation of GABAA receptors in spontaneously epileptic rats

Neurobiology of Disease
Marco I GonzalezAmy R Brooks-Kayal

Abstract

In this study, we analyzed the impact that spontaneous seizures might have on the plasma membrane expression, composition and function of GABAA receptors (GABAARs). For this, the tissue of chronically epileptic rats was collected within 3h of seizure occurrence (≤3h group) or at least 24h after seizure occurrence (≥24h group). A retrospective analysis of seizure frequency revealed that selecting animals on the bases of seizure proximity also grouped animals in terms of overall seizure burden with a higher seizure burden observed in the ≤3h group. A biochemical analysis showed that although animals with more frequent/recent seizures (≤3h group) had similar levels of GABAAR at the plasma membrane they showed deficits in inhibitory neurotransmission. By contrast, the tissue obtained from animals experiencing infrequent seizures (≥24h group) had increased plasma membrane levels of GABAAR and showed no deficit in inhibitory function. Together, our findings offer an initial insight into the molecular changes that might help to explain how alterations in GABAAR function can be associated with differential seizure burden. Our findings also suggest that increased plasma membrane levels of GABAAR might act as a compensatory mechanism to ...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·H MöhlerU Rudolph
Feb 8, 2002·Neuron·György Buzsáki
Jun 20, 2002·Science's STKE : Signal Transduction Knowledge Environment·D R GrosshansM D Browning
Aug 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zechun Peng, Carolyn R Houser
Jan 12, 2007·Journal of Neurophysiology·Kim Ryun DrasbekKimmo Jensen
May 26, 2007·The Journal of Physiology·Joseph Glykys, Istvan Mody
Aug 24, 2007·The Journal of Biological Chemistry·Marco I GonzálezMichael B Robinson
Dec 7, 2007·Neuron·Joseph Glykys, Istvan Mody
Oct 17, 2008·Science Signaling·Ingrid V LundAmy R Brooks-Kayal
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laetitia ChauvièreChristophe Bernard
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei Zhang, Paul S Buckmaster
Dec 25, 2009·The Journal of Comparative Neurology·Khushdev K ThindPaul S Buckmaster
May 11, 2011·Neuron·Bernhard LuscherCasey L Kilpatrick
Oct 9, 2013·Experimental Neurology·Manling GeHesheng Liu

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Citations

Aug 20, 2016·Genes, Brain, and Behavior·D N StephensT Duka
May 17, 2019·Chinese Journal of Integrative Medicine·Chu-Xin DengZheng-Miao Yu
Feb 17, 2017·Neurology·Marianna SpatolaJosep Dalmau
Apr 30, 2017·Epilepsia·Suchitra JoshiJaideep Kapur
Apr 16, 2021·Cognitive Neurodynamics·Vito Di MaioFrancesco Ventriglia

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