PMID: 2494041Mar 1, 1989Paper

Seizure risk in offspring of parents with generalized versus partial epilepsy

Epilepsia
R OttmanL T Kurland

Abstract

Genetic factors are commonly assumed to play a more important role in generalized than in partial epilepsy. This study tested this hypothesis by comparing risks of unprovoked seizures in offspring of individuals with generalized versus partial epilepsy. Overall, seizure incidence was no higher in offspring of persons with generalized epilepsy than in offspring of those with partial epilepsy. The number of affected offspring was about three times that expected from population incidence rates, regardless of whether the parent had partial or generalized epilepsy. For the subgroup of generalized cases with absence seizures, however, seizure incidence in offspring was about three times as high as for partial cases. The higher incidence in offspring of absence cases was only partly explained by a higher proportion of absence than partial cases with two factors associated with high risk in relatives, namely early age at onset and idiopathic epilepsy. Offspring of absence cases had higher risk than offspring of other cases not only for absence seizures, but for other seizure types as well, suggesting that absence epilepsy is not genetically distinct from other seizure types of epilepsy. These results suggest that the higher incidence s...Continue Reading

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Citations

Mar 31, 1998·Archives of Neurology·R OttmanN Risch
Aug 1, 1996·Annals of Neurology·S F BerkovicJ L Hopper
Jul 12, 2002·Statistics in Medicine·Melodie WinawerDaniel Rabinowitz
Oct 1, 1990·Journal of Neurology·N Senanayake
May 24, 2003·Seizure : the Journal of the British Epilepsy Association·A BianchiUNKNOWN LICE Episcreen Group
Mar 1, 1993·Seizure : the Journal of the British Epilepsy Association·N Buchanan, G Scambler
Jun 1, 1994·Seizure : the Journal of the British Epilepsy Association·S L Lannon
May 1, 1995·Nature Genetics·R OttmanM L Scheuer
Oct 9, 2002·Epilepsia·E AndersonUNKNOWN ILAE Genetics Commission
Jun 14, 2003·The Neurologist·Melodie R Winawer
Jul 1, 1991·Epilepsia·R OttmanL T Kurland
Apr 1, 1996·Epilepsia·R OttmanM Susser
Dec 20, 2005·Epilepsia·Ruth Ottman
Dec 20, 2005·Epilepsia·Melodie R Winawer, Shlomo Shinnar
Oct 7, 2010·Genome Medicine·Heather C Mefford, John C Mulley
Jun 23, 2011·PloS One·Kellen D WindenJerome Engel
Jan 29, 2014·Brain : a Journal of Neurology·Anna L PeljtoRuth Ottman
Aug 26, 2014·Current Genetic Medicine Reports·Heather C Mefford
Dec 8, 2004·Epilepsy Research·R Renuka Nair, Sanjeev V Thomas
Mar 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·C Lenti
Feb 25, 2006·Epilepsy & Behavior : E&B·Melodie R Winawer
Aug 26, 2015·Genome Medicine·Candace T Myers, Heather C Mefford
Apr 12, 2002·Seizure : the Journal of the British Epilepsy Association·Giovanni Regesta, Paolo Tanganelli
May 6, 2003·American Journal of Human Genetics·Fengzhu SunFaina Schwartz
Aug 29, 1998·Journal of Child Neurology·D S MacIntoshC S Camfield
Jul 1, 1990·Developmental Medicine and Child Neurology·S J Wallace
Oct 23, 2020·Epilepsia·Marie GrammDennis Lal

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