Seizure semiology: an important clinical clue to the diagnosis of autoimmune epilepsy

Annals of Clinical and Translational Neurology
Rui-Juan LvXiao-Qiu Shao

Abstract

The purpose of this study is to analyze the seizure semiologic characteristics of patients with autoimmune epilepsy (AE) and describe the investigation characteristics of AE using a larger sample size. This observational retrospective case series study was conducted from a tertiary epilepsy center between May 2014 and March 2017. Cases of new-onset seizures were selected based on laboratory evidence of autoimmunity. At the same time, typical mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS) were recruited as the control group from the subjects who underwent presurgical evaluation during the same period. A total of 61 patients with AE were identified. Specific autoimmune antibodies were detected in 39 patients (63.93%), including anti-VGKC in 23 patients (37.70%), anti-NMDA-R in 9 patients (14.75%), anti-GABAB-R in 6 patients (9.84%), and anti-amphiphysin in 1 patient (1.64%). Regarding the seizure semiology, no significant differences were noted between AE patients with autoantibody and patients with suspected AE without antibody. Compared to typical MTLE patients with HS, both AE patients with autoantibody and patients with suspected AE without antibody had the same seizure semiologic characteristic...Continue Reading

References

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Citations

Sep 17, 2020·Journal of Environmental and Public Health·Joseph O Yaria, Adesola Ogunniyi
Sep 22, 2019·International Journal of Molecular Sciences·Gabriela Dumitrita StanciuAndrei Luca
Oct 13, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhen FanLi Pan
Mar 5, 2021·Seizure : the Journal of the British Epilepsy Association·Angélica Lizcano-MenesesFernando Cendes
Apr 27, 2021·Frontiers in Neurology·Marie SüßeFelix von Podewils
Jul 23, 2021·CNS Neuroscience & Therapeutics·Tao-Ran LiRui-Juan Lv
Jul 21, 2021·Seizure : the Journal of the British Epilepsy Association·Lu ChenQian Wu

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.