Seizures, Cerebral Shutdown, and SUDEP

Epilepsy Currents
Alireza Bozorgi, Samden D Lhatoo

Abstract

Several potential pathophysiologic phenomena, including "cerebral shutdown," are postulated to be responsible for SUDEP. Since the evidence for a seizure-related mechanism is strong, a poor understanding of the physiology of human seizure termination is a major handicap. However, rather than a failure of a single homeostatic mechanism, such as postictal arousal, it may be a "perfect storm" created by the lining up of a several factors that lead to death.

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Citations

Jul 19, 2014·Journal of the Neurological Sciences·Josef Finsterer, Karim Wahbi
Aug 12, 2014·The Journal of Physiology·Gordon F BuchananGeorge B Richerson
Aug 6, 2016·Epilepsy & Behavior : E&B·Dirk-Matthias AltenmüllerRainer Surges
Jun 21, 2019·Neurology·Chloe VerducciOrrin Devinsky
Feb 19, 2016·Journal of Neurophysiology·Michael A Hajek, Gordon F Buchanan
Dec 24, 2019·Experimental Neurology·Alexandra N PetrucciGordon F Buchanan
Dec 29, 2020·BMC Medical Informatics and Decision Making·Bishal LamichhaneXiaoqian Jiang
Aug 4, 2021·Autonomic Neuroscience : Basic & Clinical·Maromi Nei, Allyson Pickard

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