Seizures in children with dysembryoplastic neuroepithelial tumors of the brain--A review of surgical outcomes across several studies

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Adrianna Ranger, David Diosy

Abstract

In children and adolescents, dysembryoplastic neuroepithelial tumors (DNETs) of the brain present with seizures almost 100% of the time, potentially creating significant long-term morbidity and disability despite the generally indolent course of the lesion. These tumors also tend to be quite resistant to anti-epileptic drugs which, themselves, can be associated with long-term side effects and resultant disability. Many clinicians advocate early surgical resection of these lesions, but how effective this approach is, and how aggressive tumor removal should be, continues to be debated. We performed a systematic review of the relevant literature to identify all reports of DNET resections in pediatric patients published over the past 20 years. In all, over 3000 MEDLINE abstracts were reviewed, ultimately resulting in 13 studies with 185 pediatric DNET patients to review. Surgical resection of the lesion was effective at improving seizures in over 98% of patients and at achieving long-term seizure freedom in 86%. Surgical resection of DNETs also appeared to be quite safe, with no reported perioperative deaths and an overall rate of postoperative complications of 12%; the vast majority of these complications were transient. Total gro...Continue Reading

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Citations

Dec 25, 2015·Medical Oncology·M BraoudakiE Kanavakis
Oct 24, 2015·Journal of Pathology and Translational Medicine·Yeon-Lim Suh
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Gianluca TrevisiHugues Duffau
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tadanori TomitaTatiana Pundy
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthew T Brown, Frederick A Boop
Sep 22, 2018·Neuro-oncology·Thankamma AjithkumarKieren Allinson
May 6, 2019·Journal of Neuro-oncology·Jeyul YangJi Hoon Phi
May 25, 2018·British Journal of Neurosurgery·Cihan IslerMustafa Uzan
Mar 25, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A G MelikyanM D Varukhina
Aug 3, 2017·Der Radiologe·W ReithR Mühl-Benninghaus
Oct 31, 2015·Journal of Neuro-oncology·Phillip A BonneyMichael E Sughrue
Dec 15, 2020·Seminars in Ultrasound, CT, and MR·Manohar KuruvaRyan B Peterson

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Methods Mentioned

BETA
surgical resection
biopsy

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