Seizures in lung transplant recipients

Epilepsia
B V VaughnT M Egan

Abstract

We wished to assess organ transplant recipients, who incur a significant risk for seizures. We reviewed 85 lung transplants performed in 81 patients at the University of North Carolina hospitals between 1991 and 1994. All patients were reviewed for age, reason for transplant, detailed description of seizures, neurological examination, medications, and laboratory results, including cyclosporine level, EEG, and brain imaging. Eighteen of 81 (22%) patients experienced seizures. Patients aged < 25 years had the greatest risk of seizures and 15 of the 18 patients had cystic fibrosis. Sixteen of the 18 (89%) patients, by history, had partial-onset seizures. Eleven of the 18 (61%) patients had seizures < or = 10 days after initiation of intravenous methylprednisolone for allograft rejection. Two patients had seizures associated with sustained hypertension: 1 of these patients was simultaneously being treated for rejection. Four patients had strokes (1 before transplant) and seizures. Two patients were receiving imipenem. Magnetic resonance imaging (MRI) of the brain demonstrated areas of increased T2 signal in 8 of 9 patients. Our findings demonstrate multiple etiologies for seizures in our transplant recipients. However, we believe t...Continue Reading

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Citations

Jul 22, 1998·Epilepsia·E TaubøllL Gjerstad
Nov 23, 2006·Epilepsia·Emily Oby, Damir Janigro
Jul 18, 2009·Anesthesia and Analgesia·Daniel FriedmanLawrence J Hirsch
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Mar 3, 2009·Journal of the Neurological Sciences·Sasa A ZivkovićKenneth McCurry
Jun 3, 2008·Neurologic Clinics·Karine J Abou Khaled, Lawrence J Hirsch
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Jul 30, 2016·Pediatric Clinics of North America·Albert Faro, Alexander Weymann
Jun 15, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Vanessa SoetantoHarpreet Singh Grewal
Sep 21, 2021·Frontiers in Molecular Neuroscience·Ryan J LongeneckerJonathan Kil

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