Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn, 1990-1998

Mayo Clinic Proceedings
P A NyquistM Rodriguez

Abstract

To evaluate seizure type, electroencephalographic findings, and response to antiepileptic drug (AED) treatment in patients with multiple sclerosis (MS) and coexistent seizure activity. We reviewed the medical records of all patients seen at the Mayo Clinic in Rochester, Minn, with the diagnosis of MS and seizures between 1990 and 1998. During the study period, 5715 patients with MS were identified. Of these 5715 patients, 51 (0.89%) experienced seizure activity. The most common ictal behavior was a generalized tonic-clonic seizure in 35 patients (68.6%). Simple or complex partial seizures occurred in 11 patients (21.6%), and 18 patients (35.3%) had only 1 seizure episode. Focal motor status epilepticus, ie, epilepsia partialis continua, occurred in 3 patients (5.9%) and was associated with cognitive impairment. In 37 patients (72.5%), the initial seizure presentation was after the diagnosis of MS. A seizure resulted in the diagnosis of MS or occurred before the diagnosis of MS but after other symptoms or signs of demyelinating disease in 14 patients (27.4%). Electroencephalography was performed in 43 patients. Electroencephalographic findings included diffuse or localized nonspecific background slowing in 19 patients (44.2%), u...Continue Reading

References

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Citations

Jun 23, 2011·Therapeutic Advances in Neurological Disorders·João Carlos Correia de SaBernd C Kieseier
Sep 25, 2012·Epilepsy Research·Hitoshi NakanoTetsuro Konishi
Mar 14, 2008·Epilepsia·Marcus KochJacques De Keyser
Aug 2, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A M G SasG H Visser
Jul 15, 2015·Neuroscience·Caspar E P van MunsterJeroen J G Geurts
May 18, 2013·Neurocase·Małgorzata Urban-KowalczykJolanta Rabe-Jabłońska
Sep 24, 2010·Multiple Sclerosis : Clinical and Laboratory Research·H CatenoixS Vukusic
Nov 5, 2010·Arquivos de neuro-psiquiatria·Cynthia Dumas Viveiros, Regina Maria Papais Alvarenga
Dec 24, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarrieOlaf Stuve
Jan 28, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarrieNadia Reider
Jul 8, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giangaetano D'AleoPlacido Bramanti
Nov 1, 2012·Acta neurologica Belgica·Masoud EtemadifarPeyman Roomizadeh
Apr 24, 2003·Multiple Sclerosis : Clinical and Laboratory Research·P StrianoP Boccella
Jan 6, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sara GaspariniUNKNOWN Epilepsy Study Group of the Italian Neurological Society
Jan 3, 2021·Applied Psychophysiology and Biofeedback·Fereshteh ShakibaeiNarges Darvishi Jazi
Nov 13, 2020·Frontiers in Neuroscience·Andras Attila HorvathAnita Kamondi

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