PMID: 9663798Jul 15, 1998Paper

Seizures, memory and synaptic plasticity

Seizure : the Journal of the British Epilepsy Association
I C Reid, C A Stewart

Abstract

Electrophysiological studies of the rodent hippocampus show that repeated seizure activity has a profound, deleterious effect on an important form of synaptic plasticity (long-term potentiation, LTP) which has been suggested to underlie memory formation. It appears that seizure activity incrementally causes an indiscriminate and widespread induction of long-term potentiation, consuming and thereby reducing overall hippocampal plasticity available for information processing. Consistent with this finding, severe deficits in a form of learning known to be mediated by hippocampal function are observed in rat subjected to repeated electroconvulsive seizures (ECS). The effect on synaptic function gradually resolves over a period of around 40 days, paralleling the time course of the transitory cognitive impairment seen following electrical seizure induction (ECT) in humans being treated for severe affective disorder. The effect is likely to be mediated by NMDA receptor activation during seizure activity, as the phenomenon can be prevented by the administration of a non-competitive NMDA receptor associated channel blocker (ketamine) immediately before seizure induction. The mechanisms described may account for the inter-ictal cognitive...Continue Reading

References

Jul 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·D WeeksR E Kendell
Aug 29, 1994·Neuroscience Letters·C A Stewart, I C Reid
Jul 1, 1994·The American Journal of Psychiatry·D P DevanandH A Sackeim
May 1, 1956·Electroencephalography and Clinical Neurophysiology·F MORRELLH H JASPER
Jun 1, 1949·Journal of Comparative and Physiological Psychology·D O HEBB

❮ Previous
Next ❯

Citations

Jan 11, 2005·Neurotoxicity Research·Ian C Reid, Caroline A Stewart
Mar 15, 2011·European Archives of Psychiatry and Clinical Neuroscience·Laura KranasterAlexander Sartorius
Jun 5, 2008·Journal of Neural Transmission·Chittaranjan AndradeJ Suresh Chandra
Jul 11, 2006·Wiener medizinische Wochenschrift·Michael PrapotnikAndreas Conca
Sep 21, 2000·Neuroscience Research·S MizuhashiN Matsuki
Feb 25, 2000·Neuroscience Letters·C Papatheodoropoulos, G Kostopoulos
Dec 31, 2003·Nuclear Medicine and Biology·Rikki N Waterhouse
Feb 28, 2002·The European Journal of Neuroscience·P J FrenchT V Bliss
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Richard J PorterPeter Gallagher
Oct 13, 2009·Journal of Psychiatric Practice·Nancy A Payne, Joan Prudic
Dec 6, 2007·Epilepsia·Kimford J Meador
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Jun 27, 2000·The Journal of ECT·H A Sackeim
Jul 6, 2007·The European Journal of Neuroscience·Jun-Li ZhouGregory L Holmes
Jul 22, 2010·The European Journal of Neuroscience·Robbert G E NotenboomPierre N E de Graan
May 20, 2008·Seizure : the Journal of the British Epilepsy Association·Qian ZhaoGregory L Holmes
Apr 13, 2013·Behavioural Brain Research·Luís Bruno da Cruz e Alves-de-MoraesTelma Gonçalves Carneiro Spera de Andrade
Sep 8, 2007·Pain·Thomas KleinRolf-Detlef Treede
Feb 15, 2005·Physiology & Behavior·An TorremansPeter Paul De Deyn
Jun 27, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Björn Wahlund, Dietrich von Rosen
Aug 4, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Min DongYu-Tao Xiang
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·I C Reid, C A Stewart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.