Seizures Related to Hypomagnesemia: A Case Series and Review of the Literature

Child Neurology Open
Becky Biqi ChenGuido Filler

Abstract

Childhood seizures have various nonneurological etiologies. The patient's magnesium levels should be measured when evaluating afebrile seizures. The purpose of the current case series is to describe a systematic approach for diagnosing hypomagnesemia using 3 recent patient cases. This case series describes 3 patients with unprovoked hypomagnesemia-associated seizures. The authors describe the differential diagnosis, pathophysiology, and the workup of hypomagnesemia-associated seizures. Hypomagnesemia contributed to the cause of the seizures in all 3 cases. Various causes of hypomagnesemia were investigated, including genetic etiologies. All 3 patients were maintained at a magnesium level >0.65 mmol/L, which improved or eliminated the seizures. Magnesium levels should always be measured when trying to determine the etiology of seizures. Hypomagnesemia and afebrile seizures should be treated with the goal of maintaining a magnesium concentration >0.65 mmol/L. Although rare, genetic causes of hypomagnesemia should be considered, once common causes of hypomagnesemia are ruled out.

References

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Citations

Aug 25, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Peter Zhan Tao WangGuido Filler
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cezary GrochowskiRyszard Maciejewski
Jun 1, 2018·International Journal of Endocrinology·Abdullah M Al AlawiHenrik Falhammar
Jun 9, 2018·Nutrients·Anna E KirklandKathleen F Holton

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