SEL1L expression in non-small cell lung cancer

Human Pathology
Stefano FerreroIda Biunno

Abstract

SEL1L gene product plays a role in cell transformation and tumor progression in human breast, pancreas, esophageal, and prostate cancer. SEL1L expression was evaluated in a series of 76 surgically resected non-small cell lung carcinomas to investigate its clinical significance. SEL1L is scarcely detectable in normal lung, whereas in the initial stages of cell transformation, it becomes consistently expressed with evident staining in bronchial squamous metaplasia and in associated dysplastic changes. SEL1L immunoreactivity can be detected both in the cytoplasm and less commonly in the nuclei; the subcellular location correlates with tumor histotype, with cytoplasmic immunoreactivity being most prevalent in squamous cell carcinomas (P = .0005) and nuclear immunoreactivity being associated with adenocarcinomas (P = .02). Nuclear import and export signals are present in the SEL1L coding sequence, justifying the different subcellular location of the protein. SEL1L immunoreactivity was inversely correlated with tumor grade (P = .05); when considering only the adenocarcinomas, a stronger association was found (P = .006). SEL1L messenger RNA and protein evaluation in lung cancer cell lines confirmed the expression of the gene and the d...Continue Reading

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Citations

Feb 22, 2012·Digestive Diseases and Sciences·Hassan AshktorabIda Biunno
Nov 23, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marina CardanoIda Biunno
May 28, 2011·Journal of Cellular Physiology·Monica CattaneoIda Biunno
Dec 8, 2017·Journal of Cellular Physiology·Andrea BarbieriIda Biunno
Aug 18, 2017·Journal of Cellular Physiology·Marina CardanoIda Biunno
May 22, 2019·The Journal of Pathology. Clinical Research·Marta MellaiDavide Schiffer

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