PMID: 8594921Dec 1, 1995Paper

Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs

The American Journal of Physiology
M J MurrayStephen J DeMichele

Abstract

We examined the effect of substituting linoleic acid (LA) with eicosapentaenoic acid (EPA) and gamma-linolenic acid (gamma-LA), precursors of trienoic and monoenoic eicosanoids, respectively, on acute lung injury (ALI). Three groups (n = 8/group) of pigs were fed enteral diets containing LA (diet A), EPA (diet B), or EPA+gamma-LA (diet C) for 8 days. ALI was then induced with a 0.1 mg/kg bolus of Escherichia coli endotoxin followed by a continuous infusion for 4 h (0.075 mg.kg-1.h-1). Pulmonary arterial and capillary wedge pressures, cardiac index (CI), arterial blood gases, arterial O2 content, and plasma thromboxane B2 (TxB2) were measured. Arterial PO2 decreased at 20 min in animals fed diet A. This change was attenuated with diets B and C. The EPA- and EPA + gamma-LA-enriched diets attenuated the fall in O2 delivery at 20 min, an improvement that was sustained throughout the 4-h study period with the EPA+gamma-LA-enriched diet only. This improvement in O2 delivery was due not only to the improved arterial PO2, but also to the maintenance of CI at 20 min in animals fed diets B and C and throughout the 4-h study period in animals fed diet C. At 4 h, TxB2 increased 10-fold over baseline in animals fed diet A, whereas in animal...Continue Reading

Citations

Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Alessandro Pontes-ArrudaPierre Singer
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Barry A Mizock, Stephen J DeMichele
Feb 16, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Konstantin MayerWerner Seeger
Nov 25, 2020·BMJ Nutrition, Prevention & Health·Philip C Calder

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