Select the best: novel biocatalysts for industrial applications

Trends in Biotechnology
Monika Konarzycka-Bessler, Karl-Erich Jaeger

Abstract

The number of biocatalysts needed for biotechnological applications is increasing rapidly, necessitating the development of novel identification systems. To date, strategies based on high-throughput screening and selection are applied, with the latter enabling a desired phenotype to survive under appropriate conditions. The groups of Witholt and de Lorenzo have devised a novel selection system, comprising a transcriptional regulator that is activated upon binding to the product of a biocatalytic reaction, which paves the way for easier selection of many different biocatalysts.

References

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Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephan van Sint FietBernard Witholt

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Citations

Oct 3, 2006·Applied and Environmental Microbiology·Helge HenningKarl-Erich Jaeger
May 19, 2010·International Journal of Molecular Sciences·Pedro Fernandes
May 16, 2009·Biotechnology Advances·J D CarballeiraJ V Sinisterra
Apr 24, 2007·The FEBS Journal·Ykelien L BoersmaWim J Quax
Apr 13, 2013·The FEBS Journal·Teunke van RossumJohn van der Oost
Jun 2, 2012·The Quarterly Journal of Experimental Psychology : QJEP·Ángel TabulloAlberto Yorio

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