Selected Biomarkers Correlate with the Origin and Severity of Sepsis.

Mediators of Inflammation
M HolubO Beran

Abstract

The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortiso...Continue Reading

References

Jul 1, 1992·Infection and Immunity·C E HackL A Aarden
Mar 1, 1990·Critical Care Medicine·R M ScheinB Chernow
Mar 1, 1995·The Journal of Infectious Diseases·R LandmannT Calandra
Jun 1, 1995·The Journal of Infectious Diseases·P M JansenC E Hack
Mar 19, 1994·Lancet·A MarchantM Goldman
Aug 1, 1994·Intensive Care Medicine·J L MoranP Leppard
Apr 29, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·E ArranzJ A Garrote
Jan 14, 2000·Journal of Clinical Immunology·D P OlszynaT Van Der Poll
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·K F JoostenA C Hokken-Koelega
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Oct 16, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Burke A Cunha
Feb 3, 2005·The Journal of Infectious Diseases·Anne-Sophie W MøllerPeter Kierulf
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Clementien L VermontRonald de Groot
Apr 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Fernando A BozzaPatrícia T Bozza
Jun 20, 2007·Scandinavian Journal of Infectious Diseases·Hannele AaltoHeikki Repo
Oct 5, 2012·Clinical Microbiology Reviews·Konrad ReinhartChristiane S Hartog
May 22, 2013·Mediators of Inflammation·Michal HolubPavel Chalupa
Sep 14, 2013·Critical Care : the Official Journal of the Critical Care Forum·Jason PhuaAmartya Mukhopadhyay
Jun 3, 2014·Journal of Translational Medicine·Tsai-Hsia HongYih-Sharng Chen
Mar 13, 2015·Germs·Valeriu GheorghiţăFlorin Alexandru Căruntu
Nov 26, 2015·Archivos argentinos de pediatría·Istemi H CelikUgur Dilmen
Feb 4, 2016·International Journal of Molecular Sciences·Kok-Khun YongShun-Fa Yang
Jun 7, 2016·Lancet·Fiona McGillTom Solomon
Sep 17, 2016·Scandinavian Journal of Immunology·N V CavalcantiJ B Correia
Oct 6, 2016·Intensive Care Medicine Experimental·Peter BentzerAdam Linder
Dec 3, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Shuhua LiJiong Yang
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Oct 3, 2017·European Journal of Internal Medicine·Frederik Fruergaard Larsen, J Asger Petersen
Oct 13, 2017·Advances in Therapy·Jordi RelloSilvia Moyano

❮ Previous
Next ❯

Citations

Nov 2, 2019·International Journal of Molecular Sciences·Min HuangJingqian Su
Jul 3, 2020·Cardiology Research and Practice·Yufeng CaiMingyi Zhao
Sep 29, 2020·Journal of Translational Internal Medicine·Jiaojiao ChaoRongli Yang
May 18, 2021·SAGE Open Medicine·Panid BorhanjooLillian Chow

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assays
blood collection
ELISA

Software Mentioned

STATISTICA
Stat

Related Concepts

Related Feeds

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Related Papers

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
L A van VughtT van der Poll
© 2022 Meta ULC. All rights reserved