Abstract
To explore whether peripheral inflammatory, metabolic, and hemostatic parameters could predict the pathogenesis of successive bilateral sudden sensorineural hearing loss (SSNHL). This study reviewed 33 patients with successive bilateral SSNHL and 215 patients with unilateral SSNHL. Clinical characteristics and hematological parameters were compared, including the inflammatory markers (like neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet lymphocyte ratio (PLR)) and metabolic features (including hypertension, triglyceridemia, dyslipidemia, and hyperglycemia), as well as hemostatic indices (including prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen). In the successive bilateral SSNHL group, older average onset age (48.67 ± 15.36 vs. 42.71 ± 13.58, p < 0.05), higher male to female ratio (18 : 15 vs. 112 : 103, p > 0.05), and poorer therapeutic efficacy (12% vs. 59%, p < 0.01) were observed than those in the unilateral SSNHL group. Compared to the unilateral SSNHL group, NLR, MLR, and PLR in the successive bilateral SSNHL group were significantly higher (NLR: 5.72 ± 2.23 vs. 4.45 ± 2.82, p = 0.01; MLR: 0.25 ± 0.15 vs. 0.17 ± 0.11, p < 0.01; PLR: 190.70 ± 69.79 vs. 1...Continue Reading
References
Jan 1, 1987·Archives of Oto-rhino-laryngology·N Yanagita, K Murahashi
Nov 1, 1996·The Laryngoscope·B L FettermanJ E Saunders
Apr 2, 1998·Laryngo- rhino- otologie·R Linke, R G Matschke
Jun 5, 2001·Journal of Epidemiology·M NakamuraG Whitlock
Jan 11, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jeong-Hoon OhYun-Hoon Choung
Aug 22, 2008·The New England Journal of Medicine·Steven D Rauch
Nov 20, 2009·Audiology & Neuro-otology·Amanda Hu, Lorne S Parnes
Apr 7, 2010·Lancet·Benjamin E SchreiberLinda M Luxon
Mar 6, 2012·Journal of Neurogenetics·Mariko HiramatsuTsutomu Nakashima
Apr 25, 2012·Clinical Research in Cardiology Supplements·Martin CanisMarkus Suckfuell
Oct 30, 2012·Atherosclerosis·Marco Matteo CicconeNicola Quaranta
Jul 12, 2013·PloS One·Thomas GaryMarianne Brodmann
Dec 18, 2013·The Journal of Laryngology and Otology·S A SaraP Friedland
Jun 4, 2014·Disease Markers·Young Joon SeoIn Seok Moon
Aug 29, 2014·PloS One·Sho KanzakiKaoru Ogawa
May 7, 2015·The Laryngoscope·Chang-Fu LinYung-Song Lin
Apr 8, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yaowen WangShixiong Tang
Jul 27, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M M CicconeN Quaranta
Citations
Oct 4, 2020·International Journal of Molecular Sciences·Jeon Gang DooSeung Geun Yeo
Jul 27, 2021·Hearing Research·Aurore SaumeJean Defourny
Sep 8, 2021·Journal of Audiology & Otology·Joo Young WooByungwoo Yoon