PMID: 9523477Apr 2, 1998Paper

Selected cellular immunity parameters in patients with Lesniowski-Crohn disease

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
R SłotwińskiM Wasik

Abstract

The study was aimed at investigating the expression of HLA-DR, CD4, CD8, CD56 and CD16 surface antigens on peripheral blood lymphocytes in patients with Crohn's disease. The percentage of rosette-forming T-cells in theophylline test was assessed simultaneously. The experiment at group consisted of 18 patients (aged 16-66) of long standing Crohn's disease history, being in the remission period and not treated by steroid antiinflammatory drugs. The percentage of lymphocytes with HLA-DR, CD4, CD8, CD56 and CD16 surface antigens was examined by means of the monoclonal antibodies (DAKO), and the APAAP procedure. The immunological test included also an assessment of the number of T-cells forming active (ARFC) and total (TRFC) rosettes in the theophylline test. Significantly increased (p < 0.001) percentage of lymphocytes with HLA-DR surface antigens was observed in patients with Crohn's disease. The percentage of lymphocytes with CD4, CD8, CD56 and CD16 surface antigens did not differ significantly from the control group, although the tendency for increase in the percentage of lymphocytes with CD8 surface antigens was clearly marked. The ratio of lymphocytes with CD4 to CD8 surface antigens and the number of T-cells forming active an...Continue Reading

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