Selected ion flow tube mass spectrometry of exhaled breath condensate headspace

Rapid Communications in Mass Spectrometry : RCM
Petr CápPatrik Spanel

Abstract

Collection of exhaled breath condensate (EBC) is a relatively simple noninvasive method of breath analysis; however, no data have been reported that would relate concentration of volatile compounds in EBC to their gaseous concentrations in exhaled air. The aim of the study was to investigate which volatile compounds are present in EBC and how their concentrations relate to results of direct breath analysis. Thus, samples of EBC were collected in a standard way from several subjects and absolute levels of several common volatile breath metabolites (ammonia, acetone, ethanol, methanol, propanol, isoprene, hydrogen cyanide, formaldehyde and acetaldehyde) were then determined in their headspace using selected ion flow tube mass spectrometry (SIFT-MS). Results are compared with those from on-line breath analyses carried out immediately before collecting the EBC samples. It has been demonstrated that SIFT-MS can be used to quantify the concentrations of volatiles in EBC samples and that, for methanol, ammonia, ethanol and acetone, the EBC concentrations correlate with the direct breath levels. However, the EBC concentrations of isoprene, formaldehyde, acetaldehyde, hydrogen cyanide and propanol do not correlate with direct breath mea...Continue Reading

References

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Citations

Nov 28, 2012·Archives of Toxicology·Gunnar Damgård NielsenPeder Wolkoff
Jul 22, 2010·Mass Spectrometry Reviews·Patrik Spaněl, David Smith
Jan 10, 2014·Cancer Medicine·Xiao-An FuMichael Bousamra
Aug 19, 2014·The Journal of Thoracic and Cardiovascular Surgery·Michael BousamraXiao-An Fu
May 31, 2017·Rapid Communications in Mass Spectrometry : RCM·Violetta ShestivskaPatrik Španěl
Sep 8, 2011·The Analyst·Xiao-An FuRichard M Higashi
May 3, 2014·Physical Chemistry Chemical Physics : PCCP·Toshio KasaiVincenzo Aquilanti
Nov 20, 2015·Journal of Breath Research·Patrik ŠpanělDavid Smith
Mar 25, 2011·The Analyst·David Smith, Patrik Spaněl
Dec 8, 2011·Analytical Chemistry·Mingxiao LiXiao-An Fu

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