Selected metastable peak monitoring: a new specific technique in quantitative gas chromatography mass spectrometry

Biomedical Mass Spectrometry
S J Gaskell, D S Millington


Using the combined electrostatic analyser-magnet scan facility of a double focusing mass spectrometer, the daughter ion peak for the fragmentation, [M-57]+ leads to [M-57-76]+, of a 5alpha-dihydrotestosterone tert-butyl-dimethylsilyl ether was monitored during gas chromatography mass spectrometry. The detection limit was approximately 20 pg. The steroid was detected by this method in an extract of human blood plasma.


Jan 1, 1976·Biochemical Society Transactions·S J Gaskell, C J Brooks


Sep 1, 1993·Journal of Clinical Pharmacology·J J MacKichan, B J Shields
Jun 13, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·R E Hill, D T Whelan
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·K WähäläK Parikka
Mar 18, 2005·The Plant Cell·Karin LjungG Sandberg
Jan 1, 1990·Annals of the New York Academy of Sciences·G F ReadK Griffiths
Nov 1, 1980·Biomedical Mass Spectrometry·S J GaskellA W Pike
Apr 1, 1980·International Journal of Andrology·R F WalkerD Riad-Fahmy
Dec 1, 1983·Biomedical Mass Spectrometry·N W DaviesM S Roberts
Oct 1, 1988·Biomedical & Environmental Mass Spectrometry·H HughesV C Parr
Jun 1, 1980·Biomedical Mass Spectrometry·D J HarvanM D Friesen
Jun 1, 1985·Analytical Chemistry·T M SackM L Gross
Oct 1, 1989·Bulletin of Environmental Contamination and Toxicology·M WhaleyJ Sy
Jan 27, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Zheng DangYue Teng
Dec 7, 2019·Mass Spectrometry Reviews·D J Harvey, Paul Vouros

Related Concepts

Chromatography, Gas-Liquid
Mass Spectrometry

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.