PMID: 9184314May 31, 1997Paper

Selecting a control group in studies of the familial coaggregation of two disorders: a quantitative genetics perspective

American Journal of Medical Genetics
M A RoyK S Kendler

Abstract

We sought to compare four different definitions of control groups in studies of the coaggregation between two disorders (A and B) on: 1) their ability to detect valid familial coaggregation; 2) their liability to artifactual evidence for familial coaggregation; and 3) their robustness to the overselection of comorbid cases. Using a quantitative genetic model of transmission, we simulated sibling pairs with familial and nonfamilial sources of comorbidity. Four different definitions of controls were tested to predict disorder B in siblings of cases vs. controls: 1) unscreened controls included subjects with A or B as well as subjects with either A or B; 2) in the symmetrical selection method, controls included only subjects without A; 3) supernormal controls included only subjects without A or B; and 4) in the pure proband method, cases included subjects with A only, and controls included only subjects without A or B. In the absence of selection bias, 1) the unscreened control and the symmetrical selection methods did not yield spurious evidence for familial coaggregation and could detect familial coaggregation; 2) the supernormal controls yielded spurious evidence of familial coaggregation; and 3) the pure proband method sometim...Continue Reading

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Citations

Feb 19, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·P Gorwood
Nov 10, 2001·Psychiatric Genetics·C M WalshE S Paykel
Feb 28, 2001·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·M A RoyM Maziade

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