Selecting drug combinations based on total equivalent dose (dose intensity)

Journal of the National Cancer Institute
R Simon, E L Korn

Abstract

We describe a mathematical model for selecting cytotoxic drugs and dosages for a combination regimen based on the antitumor activities of the drugs given as single agents and their organ-specific maximum tolerated doses. The regimen defined maximizes an approximate measure of antitumor effect subject to constraints on combined toxicity. This approach does not assume that the underlying dose-response curve is steep; nor does it assume that maximally dose-intense regimens are clinically appropriate in all situations. Whether the identified regimen is superior to standard treatments should be determined by prospective, randomized clinical trials. Determining which drugs to combine and in what proportions to combine them offers combinatorially huge numbers of possibilities. The method described here offers one approach to identifying combinations worthy of evaluation in prospective trials.

Citations

Mar 1, 1992·Breast Cancer Research and Treatment·E L Korn, R Simon
Sep 1, 1996·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M SakuraiI Hayashi
Feb 22, 2008·Journal of Veterinary Internal Medicine·A B FloryK Autio
Mar 2, 2005·Biometrics·Kai Wang, Anastasia Ivanova
Nov 7, 2003·Biometrics·Peter F ThallSang-Joon Lee
Aug 11, 2007·Biometrics·Xuelin HuangDonald A Berry
Jul 12, 2008·Statistics in Medicine·Ying Yuan, Guosheng Yin
Mar 25, 2014·Journal of the American Animal Hospital Association·Kenneth M RassnickJoanne L Intile
Mar 6, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Michiya KobayashiKazuhiro Hanazaki
Jan 18, 2019·Journal of the American Animal Hospital Association·Joanne L IntileJohn D Chretin
Oct 8, 2003·Journal of Veterinary Internal Medicine·Carol J DeRegisJohn Berg
Jan 1, 1991·Journal of Biopharmaceutical Statistics·R Simon, E L Korn
Apr 10, 2003·Journal of Veterinary Internal Medicine·Dennis BaileyMarlene Hauck
Mar 1, 2012·The Annals of Applied Statistics·Ying Yuan, Guosheng Yin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.