PMID: 8958901Nov 1, 1996Paper

Selectins and their counter receptors: a bitter sweet attraction

Thorax
F A Symon, A J Wardlaw

Abstract

Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligands (counter structures) are sialylated and fucosylated carbohydrate molecules which, in most cases, decorate mucin-like glycoprotein membrane receptors. Studies using blocking monoclonal antibodies have shown that inhibition of selectin function can ameliorate a range of inflammatory processes, offering the possibility that antagonists of selectin function may be useful in the treatment of inflammatory lung diseases such as asthma.

References

Dec 17, 1992·The New England Journal of Medicine·A EtzioniR Gershoni-Baruch
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Jul 1, 1994·The Journal of Experimental Medicine·F A SymonA J Wardlaw

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Citations

Jun 23, 1999·The American Journal of Medicine·C G Kevil, D C Bullard
Jan 17, 2004·The Annals of Thoracic Surgery·Hilde EikemoVibeke Videm
Nov 20, 2001·Current Opinion in Pharmacology·T J TorphyD E Griswold
May 13, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·S KotechaN Klein
Jul 11, 1998·Thorax·D F Rogers, G J Laurent

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