Selectins in normal pregnancy, pre-eclampsia and missed abortus

Haematologia
A AcarS Kirazli

Abstract

Selectins, are known to be increased in the serum of patients with pre-eclampsia, indicating that these molecules are possible markers of endothelial cell injury. In this study, we investigated P, E and L selectin levels in normal pregnancy, pre-eclampsia, and missed abortus. Plasma P and L selectins levels were significantly higher in normal pregnancy and pre-eclampsia than healthy controls; but plasma concentrations of E selectins were not different between these groups. Plasma P selectin was significantly higher in pre-eclampsia than normal pregnancy. Plasma concentrations of all selectins were significantly higher in missed abortus than healthy control. L selectin levels were higher in pre-eclampsia and missed abortus than normal pregnancy. We found the levels of selectins were increased in pre-eclampsia and missed abortus. Although selectins were suspected to play a role in the pathogenesis of pre-eclampsia, in conjunction with previous studies, we thought that elevated selectin levels are a non-specific consequence of endothelial injury rather than being a cause.

Citations

Sep 20, 2006·Acta Paediatrica·László DerzbachJános Rigó
Jul 21, 2004·Atherosclerosis·Vanessa A RodieIan A Greer
Sep 17, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·May Lee TjoaInge J van Wijk
Jan 13, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nikolina DochevaOffer Erez
Apr 23, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Alain StepanianUNKNOWN ECLAXIR Study Group

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