PMID: 209308Jun 1, 1978

Selection and characterization of nuclear mutations affecting mitochondria in Paramecium

Molecular & General Genetics : MGG
F Ruiz, A Adoutte

Abstract

A screening method, based upon resistance to a tetrazolium salt (TTC), is described which permitted the isolation in Paramecium of 28 mutants resistant to TTC. These mutants displayed various defects in mitochondrial functions (cytochromic content cyanide insensitive respiration). Some mutations seemed to affect directly the respiration chain while others seemed to cause indirect modifications, possibly altering mitochondrial protein synthesis. Genetic analysis of four mutants showed in all that the resistance to TTC was of nuclear origin.

References

Jun 24, 1977·Molecular & General Genetics : MGG·H BertrandC A Zagozeski
Apr 1, 1973·Journal of Bacteriology·D L EdwardsJ Horstmann
May 21, 1974·Molecular & General Genetics : MGG·A SainsardM Balméfrézol
Nov 1, 1970·European Journal of Biochemistry·M L ClaisseP P Slonimski

Related Concepts

Metazoa
Isocyanides
Cytochrome c Oxidase Subunit VIa
Antibiotic Resistance, Microbial
Study, Methodological
Mitochondria
Paramecium
Selection, Genetic
Tetrazolium Salts

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