Selection bias in occupational sperm studies

American Journal of Epidemiology
S B LarsenJ P Bonde

Abstract

Participation rates in sperm studies are typically 25-50%, and therefore it is a matter of concern whether the men who provide semen samples truly reflect the parent population. The authors analyzed data from three Danish occupational sperm studies and evaluated the relation between age and occurrence of subfertility to participation and provision of semen samples. Age and subfertility were found to be rather strong determinants of participation. Willingness to provide semen samples was greater among men aged <40 years (odds ratio (OR) = 1.8, 95% confidence interval (CI) 1.3-2.6) and among men who had experienced an infertile period (OR = 1.7, 95% CI 1.3-2.1). Furthermore, the effect of infertility was modified by occupational exposure status, thus resulting in a tendency to differential selection and possibly biased risk estimates. In a cross-sectional study, the authors recommend that priority be given to a high participation rate and that data on the basic variables be collected from the entire study population, so that it is possible to make a nonresponder analysis and evaluate bias. Such an analysis can be carried out by means of questions enquiring about infertility, genital disorders, and earlier seminal examinations. Al...Continue Reading

Citations

Aug 23, 2002·Toxicology Letters·Choon-Nam OngSin-Eng Chia
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·A Giwercman, J P Bonde
Jun 23, 1999·Reproductive Toxicology·G K LemastersG B Huszar
Dec 5, 2002·Journal of Clinical Epidemiology·Lorenzo RichiardiFranco Merletti
Jan 30, 2010·Asian Journal of Andrology·Jens Peter Ellekilde Bonde
Jan 22, 2013·Asian Journal of Andrology·Bradley D Anawalt
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Mar 3, 2007·Occupational and Environmental Medicine·L MultignerF Eustache
Aug 17, 1999·Occupational and Environmental Medicine·S B LarsenJ P Bonde
Apr 6, 2002·Occupational and Environmental Medicine·J P BondeW Zschiesche
Sep 25, 2003·Occupational and Environmental Medicine·M JoffeUNKNOWN Asclepios
Feb 3, 2005·Environmental Health Perspectives·Anna Rignell-HydbomLars Hagmar
Dec 27, 2013·Asian Journal of Andrology·Jørn Olsen, Cecilia Høst Ramlau-Hansen
Feb 4, 2014·Toxicology Letters·Omid MehrpourMohammad Abdollahi
Jan 5, 2001·Human Reproduction·T M StewartH W Baker
Aug 2, 2003·Revista do Hospital das Clínicas·Fábio Firmbach PasqualottoSami Arap
Oct 20, 2000·Journal of Occupational and Environmental Medicine·C PadungtodX Xu
Dec 26, 2002·Journal of Occupational and Environmental Medicine·Einat K SheinerIlana Shoham-Vardi
Oct 6, 2000·Environmental Health Perspectives·J M MolineP J Landrigan
Jun 7, 2006·Epidemiology·Ellen Aagaard NohrJorn Olsen
Sep 28, 2006·Epidemiology·Lone StorgaardJørn Olsen
Jun 13, 1998·Occupational and Environmental Medicine·S B LarsenJ P Bonde
Apr 30, 2005·Human Reproduction·Tarmo TiidoAleksander Giwercman
Jul 16, 2003·Epidemiology·Lone StorgaardJørn Olsen
Mar 10, 2020·Andrology·Katia Keglberg HaervigSandra Søgaard Tøttenborg
Sep 25, 2004·Human Reproduction·A MullerA Spira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.