PMID: 9421730Jan 9, 1998Paper

Selection for high levamisole resistance in Haemonchus contortus monitored with an egg-hatch assay

International Journal for Parasitology
Ruurdtje HoekstraM H Roos

Abstract

To investigate the characteristics of selection for levamisole resistance in Haemonchus contortus, the consecutive nematode generations of an in vivo selection were monitored with a newly developed egg-hatch assay. The in vivo selection was started with a population not previously exposed to any anthelmintics (SHS). At first, the levamisole resistance progressed gradually in successive nematode generations by treating sheep with increasing doses of levamisole, the initial dose being 1 mg kg-1. Treatment with 5 mg kg-1 levamisole resulted, however, in a steep increase of resistance. The selection was ended after six generations, since a level of 30 mg kg-1 levamisole, which is not far from the toxic level for sheep, was reached. The final population, RHS6, was studied in a controlled test. Treatment of RHS6-infected sheep with 30 mg kg-1 levamisole caused an 80% decrease of faecal egg output, and a reduction of 34% in worm numbers. It was remarkable that only the number of female adults was reduced. RHS6 showed a reduced viability, but a fertility similar to the starting population SHS.

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Citations

Sep 16, 2000·Molecular and Biochemical Parasitology·M OtsenR Hoekstra
Dec 29, 1999·Molecular and Biochemical Parasitology·R HoekstraM H Roos
Apr 1, 2000·Molecular and Biochemical Parasitology·R HoekstraM H Roos
Dec 22, 1998·Journal of Helminthology·M H RoosJ A Lenstra
Feb 7, 2001·Clinical Microbiology Reviews·S Geerts, B Gryseels
May 20, 2009·Parasitology Research·Georg von Samson-HimmelstjernaNicole Wirtherle
Feb 14, 2013·The Veterinary Journal·Aurora Villarroel, Megan K Halliburton
Feb 8, 2014·International Journal for Parasitology·Virginie BarrèreRoger K Prichard
Apr 3, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Paulius BaltrušisJohan Höglund

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.