PMID: 15379026Sep 24, 2004Paper

Selection of beam orientations in intensity-modulated radiation therapy using single-beam indices and integer programming

Physics in Medicine and Biology
Warren D D'SouzaLeyuan Shi

Abstract

While the process of IMRT planning involves optimization of the dose distribution, the procedure for selecting the beam inputs for this process continues to be largely trial-and-error. We have developed an integer programming (IP) optimization method to optimize beam orientation using mean organ-at-risk (MOD) data from single-beam plans. Two test cases were selected in which one organ-at-risk (OAR) and four OARs were simulated, respectively, along with a PTV. Beam orientation space was discretized in 10 degrees increments. For each beam orientation, a single-beam plan without intensity modulation and without constraints on OAR dose was generated and normalized to yield a mean PTV dose of 2 Gy and the corresponding MOD was calculated. The degree of OAR sparing was related to the average OAR MODs resulting from the beam orientations utilized with improvements of up to 10% at some dose levels. On the other hand, OAR DVHs in the IMRT plans were insensitive to beam numbers (in the 6-9 range) for similar average single-beam MODs. These MOD data were input to an IP optimization process, which then selected specified numbers of beam angles as inputs to a treatment planning system. Our results show that sets of beam angles with lower av...Continue Reading

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Citations

Jan 11, 2012·Health Care Management Science·Delal DinkBehlul Saka
Apr 25, 2008·Computer Aided Surgery : Official Journal of the International Society for Computer Aided Surgery·Joseph D MarattRichard E Hughes
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Jul 5, 2018·Computational and Mathematical Methods in Medicine·Ali GhanbarzadehSeied Rabi Mahdavi

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