PMID: 9177967Apr 1, 1997Paper

Selection of Candida glabrata strains with reduced susceptibility to azoles in four liver transplant patients with invasive candidiasis

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J FortúnA Guerrero

Abstract

The cases of four liver transplant recipients who developed invasive candidiasis (2 cholangitis, 1 perihepatic abscess, 1 candidemia) due to azole-resistant, Candida glabrata are reported. Three patients were receiving azolic compounds (2 itraconazole, 1 fluconazole) when the infection was diagnosed. All four patients received fluconazole as intestinal decontamination during the first three weeks post transplantation. The infections occurred two months after transplantation in all patients, and in one patient Candida infection was the direct cause of death. Infection of the biliary tree was the origin of candidiasis in three patients; the fourth patient developed neutropenic-related candidemia. Fluconazole MICs exceeded 16 micrograms/ml in all cases; itraconazole MICs were 16, 2, 1, and 2 micrograms/ml, respectively. The potential role of Candida species other than albicans in these patients after administration of azole agents is discussed.

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Citations

May 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R Patel
Aug 17, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E G PlayfordJ C Craig
Apr 5, 2001·Current Infectious Disease Reports·Nina Singh
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J StrahilevitzD Engelhard
Oct 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Miguel GoicoecheaScott Johns
Jun 6, 2000·The Journal of Antimicrobial Chemotherapy·N Singh
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·H NakayamaY Aoki
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Apr 10, 2003·Eukaryotic Cell·Thyagarajan SrikanthaDavid R Soll
May 18, 1999·Journal of Dental Research·S R LockhartD R Soll
Dec 9, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Allon KahnJanis E Blair
Jun 7, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J E BlairD C Mulligan
Dec 31, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shimon Kusne, Janis E Blair
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Sep 20, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·David R AndesUNKNOWN TRANSNET Investigators
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Oct 13, 2006·Current Opinion in Infectious Diseases·N Singh
Jan 5, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Minoru NagiYoshitsugu Miyazaki

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