Selection of internal standards for accurate quantification of complex lipid species in biological extracts by electrospray ionization mass spectrometry-What, how and why?

Mass Spectrometry Reviews
Miao WangXianlin Han

Abstract

Lipidomics is rapidly expanding because of the great facilitation of recent advances in, and novel applications of, electrospray ionization mass spectrometry techniques. The greatest demands have been for successful quantification of lipid classes, subclasses, and individual molecular species in biological samples at acceptable accuracy. This review addresses the selection of internal standards in different methods for accurate quantification of individual lipid species. The principles of quantification with electrospray ionization mass spectrometry are first discussed to recognize the essentials for quantification. The basics of different lipidomics approaches are overviewed to understand the variables that need to be considered for accurate quantification. The factors that affect accurate quantification are extensively discussed, and the solutions to resolve these factors are proposed-largely through addition of internal standards. Finally, selection of internal standards for different methods is discussed in detail to address the issues of what, how, and why related to internal standards. We believe that thorough discussion of the topics related to internal standards should aid in quantitative analysis of lipid classes, subc...Continue Reading

References

Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Han, R W Gross
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·B BrüggerW D Lehmann
Aug 28, 2001·Journal of Mass Spectrometry : JMS·I V ChernushevichB A Thomson
Jan 5, 2002·Analytical Chemistry·E T GanglP Vouros
May 9, 2002·Mass Spectrometry Reviews·N B Cech, C G Enke
Jun 21, 2003·Clinical Chemistry·Thomas M Annesley
Apr 2, 2005·Analytical Chemistry·Martin HermanssonPentti Somerharju
May 17, 2005·Expert Review of Proteomics·Xianlin Han, Richard W Gross
Jan 18, 2006·Journal of the American Society for Mass Spectrometry·Xianlin HanRichard W Gross
Jan 31, 2006·Journal of Lipid Research·Ulf SommerCatherine E Costello
Feb 2, 2006·Journal of Lipid Research·Xianlin HanRichard W Gross
Apr 4, 2006·Analytical Chemistry·Alexander MakarovStevan Horning
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Ruth WeltiXuemin Wang
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Xianlin Han
Jun 15, 2007·Journal of Lipid Research·Guanghou ShuiMarkus R Wenk
Oct 24, 2007·Methods in Enzymology·Dominik SchwudkeAndrej Shevchenko
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·William Craig Byrdwell
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Matthias P Wymann, Roger Schneiter
Jun 19, 2008·Rapid Communications in Mass Spectrometry : RCM·Günther EiblArmin Graber
Nov 26, 2008·Journal of Lipid Research·Alfred H MerrillMay Dongmei Wang
Jan 27, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Bo TanJ Michael Walker
Jan 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christer S EjsingAndrej Shevchenko
Feb 10, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kui YangXianlin Han
Mar 17, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marcus StåhlmanKim Ekroos

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Citations

Sep 14, 2012·Biochimie·Emilie Layre, D Branch Moody
Jul 16, 2016·Journal of Neurochemistry·Juan Pablo PalaviciniXianlin Han
Oct 30, 2016·Trends in Biochemical Sciences·Kui Yang, Xianlin Han
Apr 20, 2017·Journal of Lipid Research·Satu HänninenPentti Somerharju
Jul 11, 2019·Proteomics·Changfeng HuXianlin Han
Dec 11, 2019·Analytical and Bioanalytical Chemistry·Thomas ZülligHarald C Köfeler
Oct 1, 2020·Mass Spectrometry Reviews·Changfeng HuXianlin Han
Sep 10, 2019·Frontiers in Neurology·Matthew Wai Kin WongAnne Poljak
Dec 24, 2019·Frontiers in Cell and Developmental Biology·Johannes M F G AertsR G Boot
Nov 17, 2019·Journal of Lipid Research·Alexander TrieblMarkus R Wenk
Apr 2, 2020·Mass Spectrometry Reviews·Thomas Züllig, Harald C Köfeler
Aug 11, 2018·Analytical and Bioanalytical Chemistry·Fong-Fu Hsu
Nov 21, 2018·Biomolecules·Alexander Triebl, Markus R Wenk
Dec 19, 2018·Biomolecules·Spiro KhouryJustine Bertrand-Michel
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·John A BowdenRichard A Yost
Jan 23, 2021·Journal of Chromatographic Science·Zdenka BartosovaPer Bruheim
Jul 28, 2020·Trends in Analytical Chemistry : TRAC·Jianing Wang, Xianlin Han
Jan 26, 2021·Journal of Lipid Research·Alexander TrieblMarkus R Wenk
Feb 20, 2021·Journal of Agricultural and Food Chemistry·Xianlin Han, Hongping Ye
Jun 20, 2020·Advanced Drug Delivery Reviews·Zhuojun WuJoachim Jankowski
Apr 2, 2021·Expert Review of Proteomics·Md Mahamodun NabiMitsutoshi Setou

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