PMID: 9527268Apr 4, 1998Paper

Selection of local therapy after neoadjuvant chemotherapy in patients with stage IIIA,B breast cancer

Annals of Surgical Oncology
D N DanforthK H Cowan

Abstract

Stage IIIA,B breast cancer is commonly treated with neoadjuvant chemotherapy because of high objective response rates and improved operability. Criteria for subsequent selection of local therapy--mastectomy, radiotherapy, or both--are not well defined. We adopted a policy of selective local therapy based on rebiopsy of the breast and clinical axillary lymph node status at the time of best response to chemotherapy. Between 1980 and 1993, 126 patients with stage IIIA,B breast cancer were treated with neoadjuvant chemotherapy and definitive local therapy. The long-term incidence of locoregional failure (in-breast, chest wall, axilla, supraclavicular, neck), relapse-free survival, and overall survival was determined. The overall clinical objective response rate to chemotherapy was 95.2%. Eighty-three patients underwent mastectomy, with negative margins achieved in 91.6%. Forty-two patients had breast preservation; the overall in-breast recurrence rate was 19.0% (8 of 42 patients). The overall locoregional recurrence rate by site was: chest wall-8.7% (11 of 126 patients), axilla-8.7% (11 of 126 patients), supraclavicular-5.6% (7 of 126 patients), and neck-4.0% (5 of 126 patients). The axillary recurrence rate was 6.6% (5 of 76 patie...Continue Reading

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Citations

Dec 26, 2006·Expert Review of Anticancer Therapy·Eric Jonasch
Oct 24, 2006·International Journal of Clinical Oncology·Hideo InajiHiroki Koyama
Sep 13, 2011·The Breast Journal·Shannon M MacdonaldBruce G Haffty
Sep 24, 2002·Breast Cancer Research and Treatment·David N DanforthRonald D Neumann
Aug 28, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hideo InajiHiroki Koyama
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allen M ChenThomas A Buchholz
Mar 3, 2006·The Breast Journal·Sushil BeriwalJorge A Garcia-Young
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer A LowSandra M Swain
Jun 2, 2004·Journal of Surgical Oncology·Alexander R MillerI-Tien Yeh
Jan 11, 2005·Cancer·Allen M ChenThomas A Buchholz

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