Selection of Mesenchymal-Like Metastatic Cells in Primary Tumors - An in silico Investigation.

Frontiers in Immunology
Vipin NarangAlexandre Gouaillard

Abstract

In order to metastasize, cancer cells must undergo phenotypic transition from an anchorage-dependent form to a motile form via a process referred to as epithelial to mesenchymal transition. It is currently unclear whether metastatic cells emerge late during tumor progression by successive accumulation of mutations, or whether they derive from distinct cell populations already present during the early stages of tumorigenesis. Similarly, the selective pressures that drive metastasis are poorly understood. Selection of cancer cells with increased proliferative capacity and enhanced survival characteristics may explain how some transformations promote a metastatic phenotype. However, it is difficult to explain how cancer cells that disseminate can emerge due to such selective pressure, since these cells usually remain dormant for prolonged periods of time. In the current study, we have used in silico modeling and simulation to investigate the hypothesis that mesenchymal-like cancer cells evolve during the early stages of primary tumor development, and that these cells exhibit survival and proliferative advantages within the tumor microenvironment. In an agent-based tumor microenvironment model, cancer cell agents with distinct sets...Continue Reading

Citations

Mar 22, 2013·PLoS Computational Biology·Douglas E WhiteMelissa L Kemp
May 9, 2013·Annals of the New York Academy of Sciences·Lu-En WaiJean-Pierre Abastado
May 8, 2014·Médecine sciences : M/S·Sandra Hubert, Jean-Pierre Abastado

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