Selection of optimal programming contacts based on local field potential recordings from subthalamic nucleus in patients with Parkinson's disease.

Neurosurgery
Nuri Firat InceAviva Abosch

Abstract

In the United States, the most commonly used surgical treatment for patients with Parkinson's disease is the implantation of deep brain stimulation (DBS) electrodes within the subthalamic nucleus. However, DBS device programming remains difficult and is a possible source of decreased efficacy. We investigated the relationship between local field potential (LFP) activities in the subthalamic nucleus and the therapeutic response to programming. We recorded LFPs with macroelectrodes placed unilaterally for DBS in 4 PD patients, 3 weeks after implantation, before the start of log-term DBS. Power-frequency spectra were calculated for each of 7 possible electrode contacts or contact pairs, over multiple 5- to 10-minute quiet waking epochs and over 30-second epochs during hand movements. Subsequently, DBS devices were programmed, with testing to determine which electrode contacts or contact pairs demonstrated optimal therapeutic efficacy. For each patient, the contact pair found to provide optimal efficacy was associated with the highest energy in the beta (13-32 Hz) and gamma (48-220 Hz) bands during postoperative LFP recordings at rest and during hand movements. Activities in other frequency bands did not show significant correlatio...Continue Reading

Associated Clinical Trials

References

Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
May 23, 2002·Brain : a Journal of Neurology·Ron LevyJonathan O Dostrovsky
Nov 27, 2002·Journal of Neurosurgery·Aviva AboschAndres M Lozano
Mar 26, 2003·Stereotactic and Functional Neurosurgery·Marwan I Hariz
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Peter Brown
Jul 1, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Andre MachadoAlim-Louis Benabid
Sep 29, 2006·Journal of Neurophysiology·Moran WeinbergerJonathan O Dostrovsky
Mar 8, 2008·Parkinsonism & Related Disorders·Michael S OkunHubert H Fernandez

❮ Previous
Next ❯

Citations

May 6, 2011·Journal of Neural Engineering·A G RouseT J Denison
Oct 15, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Brandon D SwanDennis A Turner
Jan 26, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Scott StanslaskiTimothy Denison
Jun 18, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·David SatzerAviva Abosch
Sep 19, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Chunyan CaoBomin Sun
Feb 24, 2015·Frontiers in Neuroanatomy·Adriana GalvanThomas Wichmann
Apr 4, 2013·Stereotactic and Functional Neurosurgery·Paul H StypulkowskiJonathon E Giftakis
Jul 19, 2018·Journal of Neurophysiology·Nicholas MalingCameron C McIntyre
Oct 4, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackGünther Deuschl
May 20, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Luka MilosevicAlireza Gharabaghi
Sep 24, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Ning WangFangang Meng
Dec 15, 2018·Journal of Sleep Research·Elijah ChristensenJoel Zylberberg
Jul 28, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Musa OzturkNuri F Ince
Apr 14, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Harutomo HasegawaKeyoumars Ashkan
Nov 19, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Gerd TinkhauserMichael Schuepbach
May 16, 2020·Frontiers in Human Neuroscience·Ilknur TelkesJulie G Pilitsis
Nov 8, 2020·Scientific Reports·Nabin KoiralaMuthuraman Muthuraman
Dec 11, 2020·Brain : a Journal of Neurology·Yasmine M KehnemouyiHelen M Bronte-Stewart
Aug 20, 2020·Parkinsonism & Related Disorders·Charles W LuParag G Patil
Apr 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M Sohail Noor, Cameron C McIntyre
Apr 30, 2021·Neurosurgery·Anusha AllawalaSameer A Sheth
May 2, 2021·Neurobiology of Disease·Zixiao YinJianguo Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.