Selection of patients with hepatocellular carcinoma for liver transplantation: Past and future

World Journal of Hepatology
Arturo SorianoManuel Barrera

Abstract

The aim of liver transplantation (LT) for hepatocellular carcinoma (HCC) is to ensure a rate of disease-free survival similar to that of patients transplanted due to benign disease. Therefore, we are forced to adopt strict criteria when selecting candidates for LT and prioritizing patients on the waiting list (WL), to have clarified indications for bridging therapy for groups at risk for progression or recurrence, and to establish certain limits for downstaging therapies. Although the Milan criteria (MC) remain the standard and most employed criteria for indication of HCC patients for LT by far, in the coming years, criteria will be consolidated that take into account not only data regarding the size/volume and number of tumors but also their biology. This criteria will mainly include the alpha fetoprotein (AFP) values and, in view of their wide variability, any of the published logarithmic models for the selection of candidates for LT. Bridging therapy is necessary for HCC patients on the WL who meet the MC and have the possibility of experiencing a delay for LT greater than 6 mo or any of the known risk factors for recurrence. It is difficult to define single AFP values that would indicate bridging therapy (200, 300 or 400 ng...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R TakamoriL Wong
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y YaoJ P Roberts
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J FiguerasJ Santoyo
Feb 3, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Richard B FreemanUNKNOWN United Network for Organ Sharing Organ Procurement and Transplantation Network Liver and Transplantation Committee
Aug 4, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F LöheR J Schauer
Feb 17, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paige M PorrettKim Olthoff
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Sep 5, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Richard B FreemanErick Edwards
Jan 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gunda MillonigWolfgang Vogel
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·U CilloD F D'Amico
Sep 4, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P WangL M Liu
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F Y YaoJ P Roberts
Oct 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vincenzo Mazzaferro
Mar 6, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M L VolkJ A Marrero
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Aug 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christian TosoNorman M Kneteman
Aug 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francis Y YaoJohn P Roberts
Nov 27, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RavaioliA D Pinna
Jan 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian TosoNorman M Kneteman
Feb 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A KornbergU Settmacher
Apr 21, 2009·Transplantation Proceedings·M A VaronaA Soriano
Apr 22, 2009·Journal of Cancer Research and Clinical Oncology·Jia FanJian-Jun Zhang
Aug 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M FujikiS Uemoto
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francesco D'AmicoUmberto Cillo
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahsun RiazRiad Salem
Oct 14, 2009·Alimentary Pharmacology & Therapeutics·J W JangJ Y Choi
Jan 15, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E VibertR Adam
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Omar BarakatLuis Mieles
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Elizabeth A PomfretJohn Lake
May 22, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K WashburnR Freeman
Jul 17, 2010·Oncology·Morris Sherman
Jul 27, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John P RobertsFrancis Yao
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Jacques Belghiti, François Durand

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Citations

Mar 10, 2016·Annals of Surgery·Kim M Olthoff, David S Goldberg
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Qin HeXi-Ming Xu
Aug 25, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·André C TeixeiraFabio Tavora
Nov 15, 2018·Cadernos de saúde pública·Edison Moraes Rodrigues-FilhoJosé Roque Junges
Dec 14, 2019·Current Opinion in Organ Transplantation·Thomas M LeventhalSrinath Chinnakotla
Jan 5, 2018·Expert Review of Gastroenterology & Hepatology·Gui-Qian HuangMing-Hua Zheng
Mar 22, 2019·Digestive Diseases and Sciences·Anjana PillaiMichael Charlton
Apr 16, 2020·Arquivos De Gastroenterologia·Aline Lopes ChagasThaisa de Fátima Almeida Costa
Jul 24, 2020·Bioscience Reports·Zhicheng LiuGuangchao Lv
Mar 15, 2018·Annals of Hepato-biliary-pancreatic Surgery·Chun Han Nigel TanAlfred Wei Chieh Kow
Dec 12, 2018·World Journal of Hepatology·Lindsay A SobotkaLanla F Conteh
Feb 12, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emily Harding-TheobaldNeil Mehta

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