Selection of preconfigured cell assemblies for representation of novel spatial experiences

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
George Dragoi, Susumu Tonegawa

Abstract

Internal representations about the external world can be driven by the external stimuli or can be internally generated in their absence. It has been a matter of debate whether novel stimuli from the external world are instructive over the brain network to create de novo representations or, alternatively, are selecting from existing pre-representations hosted in preconfigured brain networks. The hippocampus is a brain area necessary for normal internally generated spatial-temporal representations and its dysfunctions have resulted in anterograde amnesia, impaired imagining of new experiences, and hallucinations. The compressed temporal sequence of place cell activity in the rodent hippocampus serves as an animal model of internal representation of the external space. Based on our recent results on the phenomenon of novel place cell sequence preplay, we submit that the place cell sequence of a novel spatial experience is determined, in part, by a selection of a set of cellular firing sequences from a repertoire of existing temporal firing sequences in the hippocampal network. Conceptually, this indicates that novel stimuli from the external world select from their pre-representations rather than create de novo our internal repres...Continue Reading

References

Jul 1, 1979·Maryland State Medical Journal·J Rubin
Nov 1, 1978·Experimental Neurology·A J Hill
Dec 1, 1978·Journal of Behavioral Medicine·F J Keefe
Apr 1, 1972·Journal of Experimental Child Psychology·G M Davies
Mar 10, 1995·Science·J E Lisman, M A Idiart
Jul 29, 1994·Science·M A Wilson, B L McNaughton
Aug 20, 1993·Science·M A Wilson, B L McNaughton
Jun 1, 1996·The Journal of General Physiology·R U MullerJ Pach
Dec 26, 2001·Annual Review of Psychology·Endel Tulving
Dec 24, 2002·Neuron·Albert K Lee, Matthew A Wilson
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anton SirotaGyörgy Buzsáki
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Nov 1, 2005·Neural Networks : the Official Journal of the International Neural Network Society·Francesco P BattagliaKenneth D Harris
Apr 8, 2006·Neuron·George Dragoi, György Buzsáki
Aug 22, 2006·Hippocampus·Andrew P MaurerBruce L McNaughton
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masami TatsunoBruce L McNaughton
Dec 19, 2006·Nature Neuroscience·Daoyun Ji, Matthew A Wilson
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Demis HassabisEleanor A Maguire
Apr 7, 2007·Science·Dorothy TseRichard G M Morris
Sep 11, 2007·Nature Neuroscience·Kamran Diba, György Buzsáki
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam Johnson, A David Redish
Apr 11, 2008·Annals of the New York Academy of Sciences·Daniel L SchacterRandy L Buckner
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason L GerrardCarol A Barnes
Jul 1, 1948·Psychological Review·E C TOLMAN
Jun 16, 2009·Nature Neuroscience·Mattias P Karlsson, Loren M Frank
Aug 28, 2009·Neuron·Thomas J DavidsonMatthew A Wilson
Oct 16, 2009·Nature·Christopher D HarveyDavid W Tank
Mar 13, 2010·Neuron·Anoopum S GuptaA David Redish
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thackery I BrownChantal E Stern
Jul 20, 2010·Nature Neuroscience·David DupretJozsef Csicsvari
Sep 3, 2010·The American Journal of Psychiatry·Carol A TammingaAnthony D Wagner

❮ Previous
Next ❯

Citations

Oct 2, 2014·Nature Reviews. Neuroscience·Howard Eichenbaum
Oct 27, 2015·Nature Neuroscience·Delia SilvaDavid J Foster
Jun 27, 2015·ELife·H Freyja ÓlafsdóttirHugo J Spiers
Sep 23, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mohamady El-GabyOle Paulsen
Aug 27, 2015·Wiley Interdisciplinary Reviews. Cognitive Science·Jonathan Redshaw
Mar 30, 2018·Nature Neuroscience·Ivan Soltesz, Attila Losonczy
Oct 26, 2018·Nature Reviews. Neuroscience·Hannah R Joo, Loren M Frank
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Aug 5, 2017·Neural Computation·Karl J FristonSasha Ondobaka
Mar 21, 2020·Current Biology : CB·Linnea E HerzogShantanu P Jadhav
Jan 28, 2021·Journal of Neurophysiology·Josué de Jesús Juárez-VidalesFernando Peña-Ortega
Jun 13, 2021·Nature Communications·Michael D AdoffDaniel A Dombeck
Jun 20, 2021·Trends in Cognitive Sciences·Giovanni PezzuloMaurizio Corbetta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
George Dragoi, Susumu Tonegawa
Frontiers in Computational Neuroscience
Amir H AziziSen Cheng
© 2021 Meta ULC. All rights reserved