Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer's disease.

Scientific Reports
Scott NugentSimon Duchesne

Abstract

The primary method for measuring brain metabolism in humans is positron emission tomography (PET) imaging using the tracer 18F-fluorodeoxyglucose (FDG). Standardized uptake value ratios (SUVR) are commonly calculated from FDG-PET images to examine intra- and inter-subject effects. Various reference regions are used in the literature of FDG-PET studies of normal aging, making comparison between studies difficult. Our primary objective was to determine the optimal SUVR reference region in the context of healthy aging, using partial volume effect (PVE) and non-PVE corrected data. We calculated quantitative cerebral metabolic rates of glucose (CMRg) from PVE-corrected and non-corrected images from young and older adults. We also investigated regional atrophy using magnetic resonance (MR) images. FreeSurfer 6.0 atlases were used to explore possible reference regions of interest (ROI). Multiple regression was used to predict CMRg data, in each FreeSurfer ROI, with age and sex as predictors. Age had the least effect in predicting CMRg for PVE corrected data in the pons (r2 = 2.83 × 10-3, p = 0.67). For non-PVE corrected data age also had the least effect in predicting CMRg in the pons (r2 = 3.12 × 10-3, p = 0.67). We compared the effe...Continue Reading

References

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Citations

Jan 5, 2021·Translational Neurodegeneration·Kok Pin NgUNKNOWN Dominantly Inherited Alzheimer Network
Mar 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Erin R SaitoBenjamin T Bikman
Mar 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shaïma El ChammahMarie Meyer
Apr 10, 2021·Frontiers in Neurology·Eleftherios KavroulakisEfrosini Papadaki
Aug 11, 2020·NeuroImage·Francisco J López-GonzálezPablo Aguiar
Jun 22, 2021·NeuroImage. Clinical·Colin GrootUNKNOWN Alzheimer's disease neuroimaging initiative (ADNI)
Jul 15, 2021·Scientific Reports·Sung Woo KangByoung Seok Ye
Sep 1, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas De LeirisEric Guedj

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
sandwich immunoassay
X-ray

Software Mentioned

FreeSurfer
R package relaimpo
PMOD

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