PMID: 9133704Apr 1, 1997Paper

Selection of the optimal scanning agent for thyroid cancer

Thyroid : Official Journal of the American Thyroid Association
J C Sisson


Physical and biologic principles, availability, and experience in use determine which radiopharmaceuticals will be the optimal agents to portray scintigraphically thyroid cancers. However, clinical reasoning must dictate which scanning procedure to use and when. To identify functioning thyroid nodules, and thereby exclude malignancy and also disclose the source of excess thyroid hormone, technetium Tc 99m pertechnetate is the agent of choice. To evaluate patients with metastatic differentiated thyroid cancer (DTC) for possible radiopharmaceutical therapy, low doses (no more than and probably less than 74 MBq or 2 mCi) of 131I iodide are preferred. 131I is especially necessary if dosimetry is undertaken to help prescribe the optimal therapeutic dose of 131I. For less well differentiated tumors that do not concentrate 131I, most experience has been with thallium 201, which enables depiction of most metastases, but, in time, newer agents may be found to produce superior scans. The goal of imaging of the less well differentiated cancers must be to direct additional therapy such as external beam radiation of surgical excision. It is unlikely that any scanning procedure that depends on the physiologic and biochemical activities of DT...Continue Reading


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