Selective Ability of Some CANTAB Battery Test Measures to Detect Cognitive Response to a Single Dose of Donepezil in Alzheimer Disease

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jurgita Kuzmickienė, Gintaras Kaubrys

Abstract

The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to explore which tests and their measures are able to detect cognitive change after a single dose of donepezil in Alzheimer disease (AD) patients. The aim of this study was to establish the ability of CANTAB tests and their measures to detect cognitive change after a single 5-mg dose of donepezil in treatment-naïve AD patients. We enrolled 62 treatment-naïve AD patients and 30 healthy controls in this prospective, randomized, rater-blinded study. AD patients were randomized to 2 groups: the AD+ group received donepezil after the first CANTAB testing and the AD- group remained treatment-naïve at second testing. The time period between repeated testing was 4 hours. Parallel versions of CRT, SOC, PAL, SWM, and PRM tests were used. All groups did not differ according to age, education, gender, or depression (p>0.05). AD+ and AD- groups did not differ according to MMSE. SOC, PAL, PRM, and SWM tests distinguished AD from controls. Eight measures of PAL and PRM had a strong correlation with MMSE (r>0.7). Repeated-measures ANOVA with Bonferroni post-hoc test showed the difference of change in AD+ and AD- groups between first and second CANTAB testing in 7 PAL mea...Continue Reading

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Citations

May 19, 2017·Journal of Psychopharmacology·Enes HavolliPascal Jd Goetghebeur
Jan 10, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rosemary A AbbottChristian Weimar
Dec 3, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Gintaras KaubrysVladas Taluntis
Oct 9, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jurgita Kuzmickienė, Gintaras Kaubrys
Aug 17, 2017·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN EBBINGHAUS Investigators

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