Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway

PloS One
Kirill ShumilovAlicia Rivera

Abstract

The striatum is a complex structure in which the organization in two compartments (striosomes and matrix) have been defined by their neurochemical profile and their input-output connections. The striosomes receive afferences from the limbic brain areas and send projections to the dopamine neurons of the substantia nigra pars compacta. Thereby, it has been suggested that the striosomes exert a limbic control over the motor function mediated by the surrounding matrix. However, the functionality of the striosomes are not completely understood. To elucidate the role of the striosomes on the regulation of the nigral dopamine neurons, we have induced specific ablation of this compartment by striatal injections of the neurotoxin dermorphin-saporin (DS) and dopamine neurotransmission markers have been analyzed by immunohistochemistry. The degeneration of the striosomes resulted in a nigrostriatal projections imbalance between the two striatal compartments, with an increase of the dopamine neurotransmission in the striosomes and a decrease in the matrix. The present results highlight the key function of the striosomes for the maintenance of the striatal dopamine tone and would contribute to the understanding of their involvement in some...Continue Reading

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A M Graybiel, C W Ragsdale
Jan 1, 1989·Neuroscience·J Jiménez-Castellanos, A M Graybiel
Dec 1, 1984·Neuropeptides·G GiagnoniE Gori
Jul 1, 1994·The Journal of Comparative Neurology·J M DelfsM F Chesselet
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Apr 4, 1998·Brain Research. Molecular Brain Research·A McMahonD C German
Nov 20, 1998·Brain Research Bulletin·B HontanillaJ M Giménez-Amaya
Mar 22, 2000·Nature Neuroscience·J J Canales, A M Graybiel
Nov 14, 2000·Journal of Neuroscience Methods·R G Wiley, R H Kline IV
Sep 5, 2003·Journal of Chemical Neuroanatomy·Ursula H Winzer-SerhanFrances M Leslie
Jul 24, 2004·Trends in Neurosciences·Pieter VoornCyriel M A Pennartz
Oct 16, 2004·Journal of Chemical Neuroanatomy·David Wirtshafter, Catherine V Osborn
Oct 17, 2006·Brain : a Journal of Neurology·Lynette J TippettRichard L M Faull
Mar 17, 2007·The Journal of Comparative Neurology·Belén GagoAlicia Rivera
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernard W BalleineOkihide Hikosaka
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wakoto MatsudaTakeshi Kaneko
Sep 24, 2011·Frontiers in Neuroanatomy·Jill R Crittenden, Ann M Graybiel
Jun 12, 2012·Neuron·Mitsuko Watabe-UchidaNaoshige Uchida
Oct 17, 2012·Cold Spring Harbor Perspectives in Medicine·José L LanciegoJosé A Obeso
Nov 7, 2014·Frontiers in Synaptic Neuroscience·Sean Austin O LimDaniel S McGehee
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Meiyu XuChristopher Pittenger
Aug 5, 2015·Cold Spring Harbor Perspectives in Biology·Ann M Graybiel, Scott T Grafton
Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jill R CrittendenAnn M Graybiel
Dec 16, 2016·ACS Chemical Neuroscience·Katherine R Brimblecombe, Stephanie J Cragg
Jan 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Christian BesteAlexander Münchau

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Citations

Jan 15, 2019·Journal of Neural Transmission·Dasiel O Borroto-Escuela, Kjell Fuxe
Jan 10, 2020·Journal of Neuroscience Research·Talia N Lerner

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Methods Mentioned

BETA
light microscopy
confocal

Software Mentioned

NIH ImageJ

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