Selective Ablation of the Ligament of Marshall Reduces the Prevalence of Ventricular Arrhythmias Through Autonomic Modulation in a Cesium-Induced Long QT Canine Model

JACC. Clinical Electrophysiology
Songyun WangHong Jiang

Abstract

The goal of this study was to investigate the effect of selective ablation of the ligament of Marshall (LOM) on ventricular arrhythmias (VAs). Previous studies have shown that selective stimulation of sympathetic elements of the LOM, the distal segment of the ligament of Marshall that extends beyond the left superior pulmonary vein (LOMLSPV), might induce VAs. In protocol 1, the blood pressure and ventricular effective refractory period changes as a response to LOMLSPV stimulation and left stellate ganglion (LSG) stimulation were measured before and after LOMLSPV ablation in 8 anesthetized dogs. In protocol 2, a total of 24 dogs were randomly divided into group 1 (cesium alone, n = 8), group 2 (cesium combined with LSG stimulation, n = 8), and group 3 (cesium combined with LSG stimulation after LOMLSPV ablation, n = 8). Early afterdepolarization amplitude, VA prevalence, and the tachycardia threshold (measured according to the dose of cesium administered) were compared among the groups. In protocol 1, both LOMLSPV stimulation and LSG stimulation significantly increased blood pressure and shortened the ventricular effective refractory period, both of which were significantly attenuated by LOMLSPV ablation. In protocol 2, compare...Continue Reading

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Citations

Sep 12, 2020·Pacing and Clinical Electrophysiology : PACE·Bo HeZhibing Lu
Mar 28, 2019·Frontiers in Physiology·Yanqiu LaiHong Jiang

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