PMID: 7545802Jun 1, 1995Paper

Selective accumulation of strontium-89 in metastatic deposits in bone: radio-histological correlation

Nuclear Medicine Communications
E Ben-JosefA T Porter

Abstract

The systemic administration of 89Sr has proven effective in the palliation of painful osseous metastases. Biodistribution studies with the gamma-emitter 85Sr suggest that both its uptake and retention are increased in bone metastases, where increased mineral turnover takes place. To study the pattern and nature of this process further, bones containing metastatic deposits were obtained from three patients who had previously been treated with 148 MBq of 89Sr. The bones were cut into 0.5-1.0 cm sections. The cut surfaces which faced together were marked with India ink, and adjacent sections were submitted for histology and autoradiography. Strontium deposition and retention were observed in regions which exhibited significant osteoblastic activity, mostly in areas adjacent to metastatic deposits, but also in subchondral and endosteal locations, as well as in an area corresponding to a pathological fracture with callus formation. With these exceptions, strontium deposition was not observed in histologically normal bone or within the marrow. Our findings demonstrate directly the selective nature of accumulation and retention of 89Sr and confirm previous clinical impressions.

Citations

Jun 11, 1999·The Urologic Clinics of North America·J Friedland
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·E Ben-JosefA T Porter
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Davis, R J Pither
Apr 30, 2005·Journal of Palliative Medicine·R Barton, P Kirkbride
Dec 18, 1998·American Journal of Clinical Oncology·T H Vishne, I G Ron
Sep 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·V R McCready, J M O'Sullivan
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shi-Ming TuChristopher J Logothetis
Feb 1, 1997·Annals of Medicine·E Ben-Josef, A T Porter
Aug 19, 2004·The American Journal of Hospice & Palliative Care·Howard SmithScott M Fishman

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